Myocardial sarcoplasmic reticulum Ca2+ ATPase function is increased by aerobic interval training

Ole Johan Kemi, Marcello Ceci, Gianluigi Condorelli, Godfrey L. Smith, Ulrik Wisloff

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: Reduced activity of the sarcoplasmic reticulum Ca ATPase-2a (SERCA-2a) contributes to myocardial dysfunction. Exercise training improves myocardial Ca-handling, but SERCA-2a function is uncertain. We assessed SERCA-2a activity after exercise training. METHODS: SERCA-2a function was assessed by sarcoplasmic reticulum Ca uptake in cardiomyocytes with other Ca uptake mechanisms blocked, in mice after aerobic interval training versus sedentary controls. RESULTS: We established protocols to assess SERCA-2a function, and show that aerobic interval training increases the maximal rate of Ca uptake by 30%. This is at least partly explained by reduced phospholamban-to-SERCA-2a ratio. CONCLUSION: Aerobic interval training improves myocardial SERCA-2a performance, explaining at least partly why myocardial Ca-handling improves after exercise training.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalEuropean Journal of Cardiovascular Prevention and Rehabilitation
Issue number2
Publication statusPublished - Apr 2008


  • Calcium
  • Exercise
  • Myocardium
  • Sarcoplasmic reticulum Ca ATPase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Rehabilitation
  • Public Health, Environmental and Occupational Health


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