MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions

Cristina Giacinti, Luigi Bagella, Pier Lorenzo Puri, Antonio Giordano, Cristiano Simone

Research output: Contribution to journalArticle

Abstract

During skeletal myogenesis, muscle-regulatory factors bHLH and MEF2 promote the expression of muscle-specific genes by recruiting several chromatin-modifying complexes on specific DNA regulatory sequences. A number of MyoD-interacting proteins have been reported, but whether they are recruited to the chromatin of myogenic loci, and the relationship with other chromatin bound proteins is unknown. We show that MyoD recruits cdk9/cyclin T2, together with the histone acetyltransferases p300 and PCAF, and the chromatin remodeling complex SWI/SNF, on promoters and enhancers of muscle-specific genes, and that this event correlates with the acetylation of histone tails, remodeling of chromatin, and phosphorylation of the C-terminal domain (CTD) of the RNA polymerase II at these elements.

Original languageEnglish
Pages (from-to)807-813
Number of pages7
JournalJournal of Cellular Physiology
Volume206
Issue number3
DOIs
Publication statusPublished - Mar 2006

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

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