Myofibrillar protein overdegradation in overweight patients with chronic heart failure: The relationship to serum potassium levels

Roberto Aquilani, Maria Teresa La Rovere, Paola Baiardi, Oreste Febo, Federica Boschi, Anna Maria Condino, Ornella Pastoris, Paolo Iadarola, Simona Viglio, Evasio Pasini, Andria Innocenza Bongiorno, Maurizia Dossena, Manuela Verri

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: Muscle release of the amino acid 3-methyl-histidine (3MH) is a sensitive index of myofibrillar protein overdegradation (MPO). We hypothesized that patients with chronic heart failure (CHF) could have increased muscle release of 3MH, which in turn reflects MPO, and that serum electrolyte sodium (Na+) and potassium (K+) levels may be associated with this 3MH muscle release. Methods: Thirty-one overweight outpatients (body mass index, 27 ± 4.4 kg/m2; 22 men and 9 women; age, 56 ± 8.7 y) with clinically stable CHF were studied. After a 24-hour meat-free diet and overnight fasting, patients underwent blood sampling from a cannulated arm vein (V) and concomitantly from the arterial artery (A) to determine plasma 3MH levels and to calculate the A-V difference. Serum levels of Na+ and K+ in the venous blood were determined, and the Na+/K+ ratio was calculated. Ten healthy subjects who were matched for gender, age, and body mass index served as controls and underwent the same protocol as the patients with CHF. Results: The patient group had higher arterial (P = 0.02) and venous (P = 0.005) 3MH levels but a similar A-V 3MH difference (P = 0.28) as compared with the controls. Within the CHF group, 67.7% of patients released 3MH, which resulted in a negative A-V value (P <0.02 as compared with controls). In patients with CHF, the A-V 3MH difference correlated positively with the serum K+ level (r = 0.62; P = 0.0002) and negatively with Na+/K+ ratio (r = -0.55; P = 0.002). No association was found between the A-V 3MH difference and the Na+ level. Conclusions: The study demonstrated the existence of MPO in resting overweight patients with CHF, thereby suggesting that low serum levels of K+ may contribute to MPO.

Original languageEnglish
Pages (from-to)436-439
Number of pages4
JournalNutrition
Volume30
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Histidine
Potassium
Heart Failure
Serum
Proteins
Muscles
Body Mass Index
Meat
Electrolytes
Blood Proteins
Veins
Fasting
Healthy Volunteers
Outpatients
Arteries
Sodium
Diet
Amino Acids

Keywords

  • Muscle overdegradation
  • Overweight chronic heart failure
  • Plasma 3-methyl-hystidine
  • Sarcopenia
  • Serum potassium

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Myofibrillar protein overdegradation in overweight patients with chronic heart failure : The relationship to serum potassium levels. / Aquilani, Roberto; La Rovere, Maria Teresa; Baiardi, Paola; Febo, Oreste; Boschi, Federica; Condino, Anna Maria; Pastoris, Ornella; Iadarola, Paolo; Viglio, Simona; Pasini, Evasio; Bongiorno, Andria Innocenza; Dossena, Maurizia; Verri, Manuela.

In: Nutrition, Vol. 30, No. 4, 2014, p. 436-439.

Research output: Contribution to journalArticle

Aquilani, R, La Rovere, MT, Baiardi, P, Febo, O, Boschi, F, Condino, AM, Pastoris, O, Iadarola, P, Viglio, S, Pasini, E, Bongiorno, AI, Dossena, M & Verri, M 2014, 'Myofibrillar protein overdegradation in overweight patients with chronic heart failure: The relationship to serum potassium levels', Nutrition, vol. 30, no. 4, pp. 436-439. https://doi.org/10.1016/j.nut.2013.09.010
Aquilani, Roberto ; La Rovere, Maria Teresa ; Baiardi, Paola ; Febo, Oreste ; Boschi, Federica ; Condino, Anna Maria ; Pastoris, Ornella ; Iadarola, Paolo ; Viglio, Simona ; Pasini, Evasio ; Bongiorno, Andria Innocenza ; Dossena, Maurizia ; Verri, Manuela. / Myofibrillar protein overdegradation in overweight patients with chronic heart failure : The relationship to serum potassium levels. In: Nutrition. 2014 ; Vol. 30, No. 4. pp. 436-439.
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abstract = "Objectives: Muscle release of the amino acid 3-methyl-histidine (3MH) is a sensitive index of myofibrillar protein overdegradation (MPO). We hypothesized that patients with chronic heart failure (CHF) could have increased muscle release of 3MH, which in turn reflects MPO, and that serum electrolyte sodium (Na+) and potassium (K+) levels may be associated with this 3MH muscle release. Methods: Thirty-one overweight outpatients (body mass index, 27 ± 4.4 kg/m2; 22 men and 9 women; age, 56 ± 8.7 y) with clinically stable CHF were studied. After a 24-hour meat-free diet and overnight fasting, patients underwent blood sampling from a cannulated arm vein (V) and concomitantly from the arterial artery (A) to determine plasma 3MH levels and to calculate the A-V difference. Serum levels of Na+ and K+ in the venous blood were determined, and the Na+/K+ ratio was calculated. Ten healthy subjects who were matched for gender, age, and body mass index served as controls and underwent the same protocol as the patients with CHF. Results: The patient group had higher arterial (P = 0.02) and venous (P = 0.005) 3MH levels but a similar A-V 3MH difference (P = 0.28) as compared with the controls. Within the CHF group, 67.7{\%} of patients released 3MH, which resulted in a negative A-V value (P <0.02 as compared with controls). In patients with CHF, the A-V 3MH difference correlated positively with the serum K+ level (r = 0.62; P = 0.0002) and negatively with Na+/K+ ratio (r = -0.55; P = 0.002). No association was found between the A-V 3MH difference and the Na+ level. Conclusions: The study demonstrated the existence of MPO in resting overweight patients with CHF, thereby suggesting that low serum levels of K+ may contribute to MPO.",
keywords = "Muscle overdegradation, Overweight chronic heart failure, Plasma 3-methyl-hystidine, Sarcopenia, Serum potassium",
author = "Roberto Aquilani and {La Rovere}, {Maria Teresa} and Paola Baiardi and Oreste Febo and Federica Boschi and Condino, {Anna Maria} and Ornella Pastoris and Paolo Iadarola and Simona Viglio and Evasio Pasini and Bongiorno, {Andria Innocenza} and Maurizia Dossena and Manuela Verri",
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T1 - Myofibrillar protein overdegradation in overweight patients with chronic heart failure

T2 - The relationship to serum potassium levels

AU - Aquilani, Roberto

AU - La Rovere, Maria Teresa

AU - Baiardi, Paola

AU - Febo, Oreste

AU - Boschi, Federica

AU - Condino, Anna Maria

AU - Pastoris, Ornella

AU - Iadarola, Paolo

AU - Viglio, Simona

AU - Pasini, Evasio

AU - Bongiorno, Andria Innocenza

AU - Dossena, Maurizia

AU - Verri, Manuela

PY - 2014

Y1 - 2014

N2 - Objectives: Muscle release of the amino acid 3-methyl-histidine (3MH) is a sensitive index of myofibrillar protein overdegradation (MPO). We hypothesized that patients with chronic heart failure (CHF) could have increased muscle release of 3MH, which in turn reflects MPO, and that serum electrolyte sodium (Na+) and potassium (K+) levels may be associated with this 3MH muscle release. Methods: Thirty-one overweight outpatients (body mass index, 27 ± 4.4 kg/m2; 22 men and 9 women; age, 56 ± 8.7 y) with clinically stable CHF were studied. After a 24-hour meat-free diet and overnight fasting, patients underwent blood sampling from a cannulated arm vein (V) and concomitantly from the arterial artery (A) to determine plasma 3MH levels and to calculate the A-V difference. Serum levels of Na+ and K+ in the venous blood were determined, and the Na+/K+ ratio was calculated. Ten healthy subjects who were matched for gender, age, and body mass index served as controls and underwent the same protocol as the patients with CHF. Results: The patient group had higher arterial (P = 0.02) and venous (P = 0.005) 3MH levels but a similar A-V 3MH difference (P = 0.28) as compared with the controls. Within the CHF group, 67.7% of patients released 3MH, which resulted in a negative A-V value (P <0.02 as compared with controls). In patients with CHF, the A-V 3MH difference correlated positively with the serum K+ level (r = 0.62; P = 0.0002) and negatively with Na+/K+ ratio (r = -0.55; P = 0.002). No association was found between the A-V 3MH difference and the Na+ level. Conclusions: The study demonstrated the existence of MPO in resting overweight patients with CHF, thereby suggesting that low serum levels of K+ may contribute to MPO.

AB - Objectives: Muscle release of the amino acid 3-methyl-histidine (3MH) is a sensitive index of myofibrillar protein overdegradation (MPO). We hypothesized that patients with chronic heart failure (CHF) could have increased muscle release of 3MH, which in turn reflects MPO, and that serum electrolyte sodium (Na+) and potassium (K+) levels may be associated with this 3MH muscle release. Methods: Thirty-one overweight outpatients (body mass index, 27 ± 4.4 kg/m2; 22 men and 9 women; age, 56 ± 8.7 y) with clinically stable CHF were studied. After a 24-hour meat-free diet and overnight fasting, patients underwent blood sampling from a cannulated arm vein (V) and concomitantly from the arterial artery (A) to determine plasma 3MH levels and to calculate the A-V difference. Serum levels of Na+ and K+ in the venous blood were determined, and the Na+/K+ ratio was calculated. Ten healthy subjects who were matched for gender, age, and body mass index served as controls and underwent the same protocol as the patients with CHF. Results: The patient group had higher arterial (P = 0.02) and venous (P = 0.005) 3MH levels but a similar A-V 3MH difference (P = 0.28) as compared with the controls. Within the CHF group, 67.7% of patients released 3MH, which resulted in a negative A-V value (P <0.02 as compared with controls). In patients with CHF, the A-V 3MH difference correlated positively with the serum K+ level (r = 0.62; P = 0.0002) and negatively with Na+/K+ ratio (r = -0.55; P = 0.002). No association was found between the A-V 3MH difference and the Na+ level. Conclusions: The study demonstrated the existence of MPO in resting overweight patients with CHF, thereby suggesting that low serum levels of K+ may contribute to MPO.

KW - Muscle overdegradation

KW - Overweight chronic heart failure

KW - Plasma 3-methyl-hystidine

KW - Sarcopenia

KW - Serum potassium

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