Myofibroblasts in Focal Nodular Hyperplasia of the liver

Francesco Callea, Jos Mebis, Valeer J. Desmet

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Myofibroblasts have been identified by electron microscopy in a case of Focal Nodular Hyperplasia (FNH) of the liver associated with oral contraceptives. The contractile fibroblasts were observed in the immediate vicinity of, or in close contact with, the proliferating bile ductules and in the recesses between parenchymal cells. Transitional forms between fat-storing cells (Ito cells), fibroblasts and myofribroblasts were observed. Transition of fat-storing cells to myofibroblasts, possibly under the influence of oestrogens, may be responsible for the fibrosis and retraction in FNH.

Original languageEnglish
Pages (from-to)155-166
Number of pages12
JournalVirchows Archiv A Pathological Anatomy and Histology
Volume396
Issue number2
DOIs
Publication statusPublished - Jun 1982

Fingerprint

Focal Nodular Hyperplasia
Myofibroblasts
Adipocytes
Fibroblasts
Hepatic Stellate Cells
Liver
Oral Contraceptives
Bile
Electron Microscopy
Estrogens
Fibrosis

Keywords

  • Fat storing cell
  • Focal nodular hyperplasia
  • Liver fibrosis
  • Myofibroblast
  • Oestrogens
  • ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Anatomy

Cite this

Myofibroblasts in Focal Nodular Hyperplasia of the liver. / Callea, Francesco; Mebis, Jos; Desmet, Valeer J.

In: Virchows Archiv A Pathological Anatomy and Histology, Vol. 396, No. 2, 06.1982, p. 155-166.

Research output: Contribution to journalArticle

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