Myofibroblasts in Focal Nodular Hyperplasia of the liver

Francesco Callea, Jos Mebis, Valeer J. Desmet

Research output: Contribution to journalArticle


Myofibroblasts have been identified by electron microscopy in a case of Focal Nodular Hyperplasia (FNH) of the liver associated with oral contraceptives. The contractile fibroblasts were observed in the immediate vicinity of, or in close contact with, the proliferating bile ductules and in the recesses between parenchymal cells. Transitional forms between fat-storing cells (Ito cells), fibroblasts and myofribroblasts were observed. Transition of fat-storing cells to myofibroblasts, possibly under the influence of oestrogens, may be responsible for the fibrosis and retraction in FNH.

Original languageEnglish
Pages (from-to)155-166
Number of pages12
JournalVirchows Archiv A Pathological Anatomy and Histology
Issue number2
Publication statusPublished - Jun 1982


  • Fat storing cell
  • Focal nodular hyperplasia
  • Liver fibrosis
  • Myofibroblast
  • Oestrogens
  • ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Anatomy

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