Myogenic stem cells from the bone marrow: A therapeutic alternative for muscular dystrophy?

Giuliana Ferrari; Fulvio Mavilio

doi:10.1016/S0960-8966(02)00102-5

Myogenic stem cells from the bone marrow: A therapeutic alternative for muscular dystrophy?

Giuliana Ferrari, Fulvio Mavilio

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Differentiated muscle fibres can be formed by transplanted haematopoietic stem cells in models of acute or chronic muscle regeneration, including the dystrophin-deficient mdx mouse. Muscle-forming activity can be found in adult, foetal and embryonic haematopoietic tissues. The blood-to-muscle transition may be due to transdifferentiation of haematopoietic progenitors in response to local signals provided by the regenerating muscle. These signals are only poorly provided by the muscle of the mdx mouse, since transplantation into these mice of normal C57Bl/6 bone marrow gives rise only to a minimal number of muscle fibres expressing the normal dystrophin protein (

Original language	English
Journal	Neuromuscular Disorders
Volume	12
Issue number	SUPPL.
DOIs	https://doi.org/10.1016/S0960-8966(02)00102-5
Publication status	Published - Oct 2002

Keywords

Bone marrow transplantation
Duchenne muscular dystrophy
Muscle formation
Myogenic stem cell

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Neurology

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title = "Myogenic stem cells from the bone marrow: A therapeutic alternative for muscular dystrophy?",

abstract = "Differentiated muscle fibres can be formed by transplanted haematopoietic stem cells in models of acute or chronic muscle regeneration, including the dystrophin-deficient mdx mouse. Muscle-forming activity can be found in adult, foetal and embryonic haematopoietic tissues. The blood-to-muscle transition may be due to transdifferentiation of haematopoietic progenitors in response to local signals provided by the regenerating muscle. These signals are only poorly provided by the muscle of the mdx mouse, since transplantation into these mice of normal C57Bl/6 bone marrow gives rise only to a minimal number of muscle fibres expressing the normal dystrophin protein (",

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