Myomas, pregnancy outcome, and in vitro fertilization

Carlo Bulletti, Dominique De Ziegler, Paolo Levi Setti, Ettore Cicinelli, Valeria Polli, Marco Stefanetti

Research output: Contribution to journalArticlepeer-review


Uterine fibroids have been reported in 27% of infertile women, and 50% of women with unexplained infertility become pregnant after myomectomy. The age at which a first pregnancy occurs is increasing from the thirties to the forties. This increase and the recurrence rate of leiomyomas from 15 to 30% points to the effect of myomas on the infertility. Mechanisms by which myomas may cause infertility are abnormal uterine contractility, elongation of the uterine cavity, and distortion of uterine vascularization. Surgery may have beneficial or adverse effects without clear data on its effect on the assisted reproductive technology (ART) procedures. The present study was undertaken to establish the impact of surgical removal of myomas on fertility and infertility of patients undergoing ART procedures. Patients who underwent surgical removal of myomas before in vitro fertilization (Group A) had a cumulative success rate of 33% for one to three procedures (28 clinical pregnancies in 84 patients) and delivery rate of 25% (21 live births in 84 patients). Patients who underwent in vitro fertilization without previous surgery (Group B) had a 15% clinical pregnancy rate (13 pregnancies in 84 patients) (P <0.05) and 12% delivery rate (10 deliveries in 84 pregnancies) (P <0.05). Abortion rates were 7% (8 deliveries in 84 patients) and 4% (3 deliveries in 84 patients) in Groups A and B, respectively. This study confirms the beneficial effect of surgical removal of fibroids before undergoing ART procedures.

Original languageEnglish
Pages (from-to)84-92
Number of pages9
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2004


  • Fertility
  • In vitro fertilization
  • Infertility
  • Surgical removal
  • Transvaginal ultrasound
  • Uterine myomas

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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