Myosin IXa binds AMPAR and regulates synaptic structure, LTP, and cognitive function

Alessandra Folci, Luca Murru, Elena Vezzoli, Luisa Ponzoni, Laura Gerosa, Edoardo Moretto, Fabiana Longo, Jonathan Zapata, Daniela Braida, Francesco Pistillo, Martin Bähler, Maura Francolini, Mariaelvina Sala, Silvia Bassani

Research output: Contribution to journalArticle

Abstract

Myosin IXa (Myo9a) is a motor protein that is highly expressed in the brain. However, the role of Myo9a in neurons remains unknown. Here, we investigated Myo9a function in hippocampal synapses. In rat hippocampal neurons, Myo9a localizes to the postsynaptic density (PSD) and binds the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) GluA2 subunit. Myo9a+/-mice displayed a thicker PSD and increased levels of PSD95 and surface AMPAR expression. Furthermore, synaptic transmission, long-term potentiation (LTP) and cognitive functions were impaired in Myo9a+/-mice. Together, these results support a key role for Myo9a in controlling the molecular structure and function of hippocampal synapses.

Original languageEnglish
Article number1
JournalFrontiers in Molecular Neuroscience
Volume9
Issue numberJAN
DOIs
Publication statusPublished - Jan 20 2016

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Isoxazoles
Post-Synaptic Density
Neurotransmitter Receptor
Long-Term Potentiation
Myosins
Synapses
Cognition
Neurons
Molecular Structure
Synaptic Transmission
Brain
Proteins
propionic acid

Keywords

  • AMPAR
  • Hippocampal synapses
  • LTP
  • Myosin IXa
  • PSD

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology

Cite this

Folci, A., Murru, L., Vezzoli, E., Ponzoni, L., Gerosa, L., Moretto, E., ... Bassani, S. (2016). Myosin IXa binds AMPAR and regulates synaptic structure, LTP, and cognitive function. Frontiers in Molecular Neuroscience, 9(JAN), [1]. https://doi.org/10.3389/fnmol.2016.00001

Myosin IXa binds AMPAR and regulates synaptic structure, LTP, and cognitive function. / Folci, Alessandra; Murru, Luca; Vezzoli, Elena; Ponzoni, Luisa; Gerosa, Laura; Moretto, Edoardo; Longo, Fabiana; Zapata, Jonathan; Braida, Daniela; Pistillo, Francesco; Bähler, Martin; Francolini, Maura; Sala, Mariaelvina; Bassani, Silvia.

In: Frontiers in Molecular Neuroscience, Vol. 9, No. JAN, 1, 20.01.2016.

Research output: Contribution to journalArticle

Folci, A, Murru, L, Vezzoli, E, Ponzoni, L, Gerosa, L, Moretto, E, Longo, F, Zapata, J, Braida, D, Pistillo, F, Bähler, M, Francolini, M, Sala, M & Bassani, S 2016, 'Myosin IXa binds AMPAR and regulates synaptic structure, LTP, and cognitive function', Frontiers in Molecular Neuroscience, vol. 9, no. JAN, 1. https://doi.org/10.3389/fnmol.2016.00001
Folci, Alessandra ; Murru, Luca ; Vezzoli, Elena ; Ponzoni, Luisa ; Gerosa, Laura ; Moretto, Edoardo ; Longo, Fabiana ; Zapata, Jonathan ; Braida, Daniela ; Pistillo, Francesco ; Bähler, Martin ; Francolini, Maura ; Sala, Mariaelvina ; Bassani, Silvia. / Myosin IXa binds AMPAR and regulates synaptic structure, LTP, and cognitive function. In: Frontiers in Molecular Neuroscience. 2016 ; Vol. 9, No. JAN.
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