Myotubularins and associated neuromuscular diseases

Hélène Tronchère, Alessandra Bolino, Jocelyn Laporte, Bernard Payrastre

Research output: Contribution to journalArticle

Abstract

The myotubularins are a family of phosphoinositide 3-phosphatases preferentially hydrolyzing phosphatidylinositol 3-monophosphate and also phosphatidylinositol (3,5) bis-phosphate, thus generating phosphatidylinositol and phosphatidylinositol 5-monophosphate, respectively. These phosphoinositides are known regulators of vesicular trafficking and phosphatidylinositol 5-monophosphate was also implicated in signal transduction regulation. Based on their capacity to control the level of these phosphoinositides, myotubularins are involved in the regulation of vesicular trafficking, membrane homeostasis, cytoskeleton dynamics, proliferation and apoptosis. Myotubularin dysfunctions are linked to genetic diseases: MTM1 is mutated in the X-linked congenital myotubular myopathy and MTMR2 and MTMR13 are mutated in autosomal recessive type 4B1 and 4B2 Charcot-Marie-Tooth neuropathies, respectively. This review presents the cellular functions of myotubularins and highlights their physiopathological roles in neuromuscular diseases.

Original languageEnglish
Pages (from-to)151-162
Number of pages12
JournalFuture Lipidology
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • centronuclear myopathy
  • Charcot-Marie-Tooth neuropathy
  • MTMR
  • myotubular myopathy
  • myotubularin
  • phosphoinositide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

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