Myths about the structure and function of porcine islets

Susan Bonner‐Weir, Alberto M. Davalli, Luisa Scaglia, Jennifer Hollister, Gordon C. Weir

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: As we consider using porcine islets for human transplantation many questions about the porcine ß cells arise. Issues about how many are necessary, how their mass is influenced by glycemic levels, how much they can be renewed, and how to measure their mass need to be addressed. Our knowledge from rodent studies can initially be extrapolated since there are more similarities between mammalian islets than differences. Eventually, porcine islets will need to be studied carefully for these parameters.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalXenotransplantation
Volume2
Issue number3
DOIs
Publication statusPublished - 1995

Keywords

  • diabetes
  • Islets of Langerhans
  • β‐cell

ASJC Scopus subject areas

  • Immunology
  • Transplantation

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