Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection

F. G. De Rosa, L. P. Pucillo, M. Casato, V. Agnello

Research output: Contribution to journalArticle

Abstract

The delineation of the association of HCV infection with mixed cryoglobulinemia has provided new insight into the etiology and pathogenesis of this extrahepatic manifestation of the infection. Yet very little evidence has been obtained thus far on the specific roles of virus in production of the monoclonal rheumatoid factors responsible for classic type II cryoglobulins and the associated clinical manifestations. The problematic areas of investigation that have in some instances generated misconceptions due to lack of data are reviewed. These include the prevalence and heterogeneity of mixed cryoglobulins; clinical manifestations such as liver cirrhosis, membranoproliferative glomerulonephritis, autoimmunity, progression of cryoglobulinemia from type III to type II, development of B cell malignancies; determination of lineages based on immunoglobulin gene utilization; and the anti-viral treatment of patients with mixed cryoglobulinemia.

Original languageEnglish
Pages (from-to)319-329
Number of pages11
JournalMinerva Gastroenterologica e Dietologica
Volume48
Issue number4
Publication statusPublished - Dec 2002

Fingerprint

Cryoglobulinemia
Cryoglobulins
Infection
Membranoproliferative Glomerulonephritis
Immunoglobulin Genes
Rheumatoid Factor
Autoimmunity
Coinfection
Liver Cirrhosis
B-Lymphocytes
Viruses
Neoplasms
Therapeutics

Keywords

  • Cryoglobulinemia, diagnosis
  • Cryoglobulinemia, therapy
  • Hepatitis C

ASJC Scopus subject areas

  • Gastroenterology

Cite this

De Rosa, F. G., Pucillo, L. P., Casato, M., & Agnello, V. (2002). Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection. Minerva Gastroenterologica e Dietologica, 48(4), 319-329.

Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection. / De Rosa, F. G.; Pucillo, L. P.; Casato, M.; Agnello, V.

In: Minerva Gastroenterologica e Dietologica, Vol. 48, No. 4, 12.2002, p. 319-329.

Research output: Contribution to journalArticle

De Rosa, FG, Pucillo, LP, Casato, M & Agnello, V 2002, 'Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection', Minerva Gastroenterologica e Dietologica, vol. 48, no. 4, pp. 319-329.
De Rosa, F. G. ; Pucillo, L. P. ; Casato, M. ; Agnello, V. / Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection. In: Minerva Gastroenterologica e Dietologica. 2002 ; Vol. 48, No. 4. pp. 319-329.
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