Myxofibrosarcoma: clinical and prognostic value of MRI features

Paolo Spinnato, Andrea Sambri, Tomohiro Fujiwara, Luca Ceccarelli, Roberta Clinca, Manuel Ricardo Medellin, Massimiliano De Paolis, Davide Maria Donati, Giuseppe Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

Myxofibrosarcoma is one of the most common soft tissue sarcomas in the elderly. It is characterized by an extremely high rate of local recurrence, higher than other soft tissue tumors, and a relatively low risk of distant metastases.Magnetic resonance imaging (MRI) is the imaging modality of choice for the assessment of myxofibrosarcoma and plays a key role in the preoperative setting of these patients.MRI features associated with high risk of local recurrence are: high myxoid matrix content (water-like appearance of the lesions), high grade of contrast enhancement, presence of an infiltrative pattern ("tail sign"). On the other hand, MRI features associated with worse sarcoma specific survival are: large size of the lesion, deep location, high grade of contrast enhancement. Recognizing the above-mentioned imaging features of myxofibrosarcoma may be helpful to stratify the risk for local recurrence and disease-specific survival. Moreover, the surgical planning should be adjusted according to the MRI features.

Original languageEnglish
JournalCurrent Medical Imaging Reviews
DOIs
Publication statusE-pub ahead of print - Jul 29 2020

Keywords

  • Magnetic resonance imaging
  • Neoplasm Invasivenes
  • Prognosis
  • Sarcoma
  • Soft Tissue Neoplasm
  • local neoplasm recurrence

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