n-3 fatty acid ethyl ester administration to healthy subjects and to hypertriglyceridemic patients reduces tissue factor activity in adherent monocytes

Elena Tremoli, Sonia Eligini, Susanna Colli, Paola Maderna, Patrizia Risè, Franco Pazzucconi, Franca Marangoni, Cesare R. Sirtori, Claudio Galli

Research output: Contribution to journalArticle

Abstract

n-3 Fatty acids are known to influence several functions of monocytes, including adhesion, cytokine synthesis, and superoxide generation. Monocytes express tissue factor, a membrane-bound glycoprotein, that acts as a catalyst in the coagulation cascade. In this study we evaluated the effects of administration of n-3 fatty acid ethyl esters to healthy volunteers and to hypertriglyceridemic patients on tissue factor activity (TF activity) in adherent monocytes. n-3 Fatty acids containing 75% eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (ratio of EPA to DHA, 1.34) were administered (3 g/d) to normal volunteers for 18 weeks. In addition, the effects of this treatment were evaluated in 30 hypertriglyceridemic patients for 24 weeks by using a double-blind, placebo-controlled study. TF activity in adherent monocytes was evaluated with a one-stage clotting assay. Plasma and monocyte fatty acid compositions were determined by gas-liquid chromatography. In healthy volunteers, n-3 fatty acids significantly reduced TF activity in adherent monocytes either in the unstimulated condition or after exposure to endotoxin. The inhibitory effect was observed after 12 weeks of treatment and was more pronounced after 18 weeks (>70%, P

Original languageEnglish
Pages (from-to)1600-1608
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume14
Issue number10
Publication statusPublished - 1994

Keywords

  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Procoagulant activity
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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