N-3 polyunsatured fatty acids in menopausal transition: A systematic review of depressive and cognitive disorders with accompanying vasomotor symptoms

Valentina Ciappolino, Alessandra Mazzocchi, Paolo Enrico, Marie Louise Syrén, Giuseppe Delvecchio, Carlo Agostoni, Paolo Brambilla

Research output: Contribution to journalReview article


Depression is one of the most important health problems worldwide. Women are 2.5 times more likely to experience major depression than men. Evidence suggests that some women might experience an increased risk for developing depression during “windows of vulnerability”, i.e., when exposed to intense hormone fluctuations, such as the menopause transition. Indeed, this period is associated with different symptoms, including vasomotor, depressive, and cognitive symptoms, which have all been shown to worsen as women approach menopause. Even though hormonal therapy represents the most effective treatment, side effects have been reported by several studies. Therefore, an increased number of women might prefer the use of alternative medicine for treating menopausal symptoms. N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are included among these alternative treatments. We here provide a review of studies investigating the effects of n-3 LCPUFAs on hot flashes and depressive and cognitive disorders in menopausal women. The reported results are scattered and heterogeneous. In conclusion, a beneficial role of n-3 LCPUFAs in hot flashes, and depressive and cognitive symptoms related to menopausal transition is still far from conclusive.

Original languageEnglish
Article number1849
JournalInternational Journal of Molecular Sciences
Issue number7
Publication statusPublished - Jul 1 2018



  • Affective disorders
  • Cognition
  • Depression
  • DHA
  • EPA
  • Hot flashes
  • Menopausal transition
  • N-3 LCPUFAs
  • Omega-3
  • Perimenopause

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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