n-3PUFA and Holter-derived autonomic variables in patients with heart failure: data from the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca (GISSI-HF) Holter substudy.

Maria Teresa La Rovere, Lidia Staszewsky, Simona Barlera, Roberto Maestri, Alessandro Mezzani, Paolo Midi, Roberto Marchioli, Aldo P. Maggioni, Gianni Tognoni, Luigi Tavazzi, Roberto Latini, Investigators GISSI-HF Investigators

Research output: Contribution to journalArticlepeer-review

Abstract

n-3 Polyunsaturated fatty acid (n-3PUFA) supplementation in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca (GISSI-HF) study reduced total mortality in patients with heart failure (HF), but the mechanism of action is still debated. The hypothesis of the present GISSI-HF substudy was that n-3PUFA may have beneficial effects on cardiac autonomic control. To evaluate the effect of 1 g/day of n-3PUFA vs placebo on heart rate variability variables, deceleration capacity, and turbulence slope. The GISSI-HF study enrolled patients with HF of any cause and severity. Twenty-four-hour (range 16-24 hours) Holter recordings were performed and analyzed in 388 patients at baseline, 3 months, and 12 months. Baseline characteristics were compared by using the χ(2) test, t test, or nonparametric Wilcoxon 2-sample test. Changes over time were tested by using the analysis of covariance adjusted by baseline values. At baseline, 36% of the patients were older than 70 years, 82% were men, 92% presented a left ventricular ejection fraction

Original languageEnglish
Pages (from-to)226-232
Number of pages7
JournalHeart Rhythm
Volume10
Issue number2
Publication statusPublished - Feb 2013

ASJC Scopus subject areas

  • Medicine(all)

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