N-Acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells

Walter Malorni, Roberto Rivabene, Maria Teresa Santini, Gianfranco Donelli

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Apoptosis or programmed cell death (PCD) is a type of death occurring in various physiological processes. Several data suggest that: (1) apoptosis may play a critical role in AIDS pathogenesis; (2) an increase of endocellular free radical levels can be associated with activation of previously latent HIV virus. Tumor necrosis factor (TNF), a cytokine capable of inducing oxygen free radicals and apoptosis, appears also to be involved in HIV activation. The present findings, which elucidate a relationship between the percentage of apoptotic cells, reduced glutathione (GSH) depletion and an increase of p24 antigenemia, suggest that pretreatment with N-acetylcysteine (NAC) is capable of decreasing the above-mentioned phenomena in HIV-infected U937 cells.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalFEBS Letters
Volume327
Issue number1
DOIs
Publication statusPublished - Jul 19 1993

Fingerprint

U937 Cells
Acetylcysteine
Virion
HIV
Apoptosis
Free Radicals
Chemical activation
Physiological Phenomena
Cell death
Viruses
Glutathione
Reactive Oxygen Species
Acquired Immunodeficiency Syndrome
Cell Death
Tumor Necrosis Factor-alpha
Cells
Cytokines
Oxygen

Keywords

  • Apoptosis
  • Human immunodeficiency virus (HIV)
  • Reactive oxygen intermediate (ROI)
  • Reduced glutathione (GSH), N-Acetylcysteine (NAC)
  • Tumor necrosis factor (TNF)

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

N-Acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells. / Malorni, Walter; Rivabene, Roberto; Teresa Santini, Maria; Donelli, Gianfranco.

In: FEBS Letters, Vol. 327, No. 1, 19.07.1993, p. 75-78.

Research output: Contribution to journalArticle

Malorni, Walter ; Rivabene, Roberto ; Teresa Santini, Maria ; Donelli, Gianfranco. / N-Acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells. In: FEBS Letters. 1993 ; Vol. 327, No. 1. pp. 75-78.
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