N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: Results from the EPIC cohort

Beate Pesch, Katarzyna Gawrych, Sylvia Rabstein, Tobias Weiss, Swaantje Casjens, Hans Peter Rihs, Hui Ding, Jürgen Angerer, Thomas Illig, Norman Klopp, Bas Bueno-De-mesquita, Martine M. Ros, Rudolf Kaaks, Jenny Chang-Claude, Nina Roswall, Anne Tjønneland, Kim Overvad, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Laure DossusHeiner Boeing, Steffen Weikert, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Rosario Tumino, Salvatore Panico, José Ramón Quirós, Carlos González, Mariá José Sánchez, Miren Dorronsoro, Carmen Navarro, Aurelio Barricarte, Börje Ljungberg, Mattias Johansson, David Ulmert, Roy Ehrnström, Kay Tee Khaw, Nick Wareham, Timothy J. Key, Pietro Ferrari, Isabelle Romieu, Elio Riboli, Thomas Brüning, Paolo Vineis

Research output: Contribution to journalArticle

Abstract

Background: An association betweenN-acetyltransferase2(NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladdercancerinacase- controlstudynestedintheEuropeanProspectiveInvestigationintoCancerandNutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples. Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score:OR=1.37; 95% confidence interval (CI), 1.02- 1.84, andOR=1.50; 95% CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81-1.29). Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.

Original languageEnglish
Pages (from-to)2056-2065
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 2013

    Fingerprint

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Medicine(all)

Cite this

Pesch, B., Gawrych, K., Rabstein, S., Weiss, T., Casjens, S., Rihs, H. P., Ding, H., Angerer, J., Illig, T., Klopp, N., Bueno-De-mesquita, B., Ros, M. M., Kaaks, R., Chang-Claude, J., Roswall, N., Tjønneland, A., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M. C., ... Vineis, P. (2013). N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: Results from the EPIC cohort. Cancer Epidemiology Biomarkers and Prevention, 22(11), 2056-2065. https://doi.org/10.1158/1055-9965.EPI-13-0119-T