N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: Results from the EPIC cohort

Beate Pesch, Katarzyna Gawrych, Sylvia Rabstein, Tobias Weiss, Swaantje Casjens, Hans Peter Rihs, Hui Ding, Jürgen Angerer, Thomas Illig, Norman Klopp, Bas Bueno-De-mesquita, Martine M. Ros, Rudolf Kaaks, Jenny Chang-Claude, Nina Roswall, Anne Tjønneland, Kim Overvad, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Laure DossusHeiner Boeing, Steffen Weikert, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Rosario Tumino, Salvatore Panico, José Ramón Quirós, Carlos González, Mariá José Sánchez, Miren Dorronsoro, Carmen Navarro, Aurelio Barricarte, Börje Ljungberg, Mattias Johansson, David Ulmert, Roy Ehrnström, Kay Tee Khaw, Nick Wareham, Timothy J. Key, Pietro Ferrari, Isabelle Romieu, Elio Riboli, Thomas Brüning, Paolo Vineis

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: An association betweenN-acetyltransferase2(NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladdercancerinacase- controlstudynestedintheEuropeanProspectiveInvestigationintoCancerandNutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples. Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score:OR=1.37; 95% confidence interval (CI), 1.02- 1.84, andOR=1.50; 95% CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81-1.29). Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.

Original languageEnglish
Pages (from-to)2056-2065
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 2013

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Acetyltransferases
Acetylation
Occupations
Urinary Bladder Neoplasms
Phenotype
Polycyclic Aromatic Hydrocarbons
Confidence Intervals
Amines
Occupational Exposure
Single Nucleotide Polymorphism
Case-Control Studies
Epidemiologic Studies
Cohort Studies
Smoking
Genotype
DNA

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Medicine(all)

Cite this

N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk : Results from the EPIC cohort. / Pesch, Beate; Gawrych, Katarzyna; Rabstein, Sylvia; Weiss, Tobias; Casjens, Swaantje; Rihs, Hans Peter; Ding, Hui; Angerer, Jürgen; Illig, Thomas; Klopp, Norman; Bueno-De-mesquita, Bas; Ros, Martine M.; Kaaks, Rudolf; Chang-Claude, Jenny; Roswall, Nina; Tjønneland, Anne; Overvad, Kim; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Dossus, Laure; Boeing, Heiner; Weikert, Steffen; Trichopoulos, Dimitrios; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Panico, Salvatore; Quirós, José Ramón; González, Carlos; Sánchez, Mariá José; Dorronsoro, Miren; Navarro, Carmen; Barricarte, Aurelio; Ljungberg, Börje; Johansson, Mattias; Ulmert, David; Ehrnström, Roy; Khaw, Kay Tee; Wareham, Nick; Key, Timothy J.; Ferrari, Pietro; Romieu, Isabelle; Riboli, Elio; Brüning, Thomas; Vineis, Paolo.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 22, No. 11, 11.2013, p. 2056-2065.

Research output: Contribution to journalArticle

Pesch, B, Gawrych, K, Rabstein, S, Weiss, T, Casjens, S, Rihs, HP, Ding, H, Angerer, J, Illig, T, Klopp, N, Bueno-De-mesquita, B, Ros, MM, Kaaks, R, Chang-Claude, J, Roswall, N, Tjønneland, A, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, MC, Dossus, L, Boeing, H, Weikert, S, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Panico, S, Quirós, JR, González, C, Sánchez, MJ, Dorronsoro, M, Navarro, C, Barricarte, A, Ljungberg, B, Johansson, M, Ulmert, D, Ehrnström, R, Khaw, KT, Wareham, N, Key, TJ, Ferrari, P, Romieu, I, Riboli, E, Brüning, T & Vineis, P 2013, 'N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: Results from the EPIC cohort', Cancer Epidemiology Biomarkers and Prevention, vol. 22, no. 11, pp. 2056-2065. https://doi.org/10.1158/1055-9965.EPI-13-0119-T
Pesch, Beate ; Gawrych, Katarzyna ; Rabstein, Sylvia ; Weiss, Tobias ; Casjens, Swaantje ; Rihs, Hans Peter ; Ding, Hui ; Angerer, Jürgen ; Illig, Thomas ; Klopp, Norman ; Bueno-De-mesquita, Bas ; Ros, Martine M. ; Kaaks, Rudolf ; Chang-Claude, Jenny ; Roswall, Nina ; Tjønneland, Anne ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Dossus, Laure ; Boeing, Heiner ; Weikert, Steffen ; Trichopoulos, Dimitrios ; Palli, Domenico ; Sieri, Sabina ; Tumino, Rosario ; Panico, Salvatore ; Quirós, José Ramón ; González, Carlos ; Sánchez, Mariá José ; Dorronsoro, Miren ; Navarro, Carmen ; Barricarte, Aurelio ; Ljungberg, Börje ; Johansson, Mattias ; Ulmert, David ; Ehrnström, Roy ; Khaw, Kay Tee ; Wareham, Nick ; Key, Timothy J. ; Ferrari, Pietro ; Romieu, Isabelle ; Riboli, Elio ; Brüning, Thomas ; Vineis, Paolo. / N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk : Results from the EPIC cohort. In: Cancer Epidemiology Biomarkers and Prevention. 2013 ; Vol. 22, No. 11. pp. 2056-2065.
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abstract = "Background: An association betweenN-acetyltransferase2(NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladdercancerinacase- controlstudynestedintheEuropeanProspectiveInvestigationintoCancerandNutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples. Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score:OR=1.37; 95{\%} confidence interval (CI), 1.02- 1.84, andOR=1.50; 95{\%} CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95{\%} CI, 0.81-1.29). Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.",
author = "Beate Pesch and Katarzyna Gawrych and Sylvia Rabstein and Tobias Weiss and Swaantje Casjens and Rihs, {Hans Peter} and Hui Ding and J{\"u}rgen Angerer and Thomas Illig and Norman Klopp and Bas Bueno-De-mesquita and Ros, {Martine M.} and Rudolf Kaaks and Jenny Chang-Claude and Nina Roswall and Anne Tj{\o}nneland and Kim Overvad and Fran{\cc}oise Clavel-Chapelon and Boutron-Ruault, {Marie Christine} and Laure Dossus and Heiner Boeing and Steffen Weikert and Dimitrios Trichopoulos and Domenico Palli and Sabina Sieri and Rosario Tumino and Salvatore Panico and Quir{\'o}s, {Jos{\'e} Ram{\'o}n} and Carlos Gonz{\'a}lez and S{\'a}nchez, {Mari{\'a} Jos{\'e}} and Miren Dorronsoro and Carmen Navarro and Aurelio Barricarte and B{\"o}rje Ljungberg and Mattias Johansson and David Ulmert and Roy Ehrnstr{\"o}m and Khaw, {Kay Tee} and Nick Wareham and Key, {Timothy J.} and Pietro Ferrari and Isabelle Romieu and Elio Riboli and Thomas Br{\"u}ning and Paolo Vineis",
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T1 - N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk

T2 - Results from the EPIC cohort

AU - Pesch, Beate

AU - Gawrych, Katarzyna

AU - Rabstein, Sylvia

AU - Weiss, Tobias

AU - Casjens, Swaantje

AU - Rihs, Hans Peter

AU - Ding, Hui

AU - Angerer, Jürgen

AU - Illig, Thomas

AU - Klopp, Norman

AU - Bueno-De-mesquita, Bas

AU - Ros, Martine M.

AU - Kaaks, Rudolf

AU - Chang-Claude, Jenny

AU - Roswall, Nina

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Dossus, Laure

AU - Boeing, Heiner

AU - Weikert, Steffen

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Quirós, José Ramón

AU - González, Carlos

AU - Sánchez, Mariá José

AU - Dorronsoro, Miren

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Ljungberg, Börje

AU - Johansson, Mattias

AU - Ulmert, David

AU - Ehrnström, Roy

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Key, Timothy J.

AU - Ferrari, Pietro

AU - Romieu, Isabelle

AU - Riboli, Elio

AU - Brüning, Thomas

AU - Vineis, Paolo

PY - 2013/11

Y1 - 2013/11

N2 - Background: An association betweenN-acetyltransferase2(NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladdercancerinacase- controlstudynestedintheEuropeanProspectiveInvestigationintoCancerandNutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples. Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score:OR=1.37; 95% confidence interval (CI), 1.02- 1.84, andOR=1.50; 95% CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81-1.29). Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.

AB - Background: An association betweenN-acetyltransferase2(NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladdercancerinacase- controlstudynestedintheEuropeanProspectiveInvestigationintoCancerandNutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples. Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score:OR=1.37; 95% confidence interval (CI), 1.02- 1.84, andOR=1.50; 95% CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81-1.29). Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.

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