N- and k-ras oncogenes in plasma cell dyscrasias

Paolo Corradini, Marco Ladetto, Giorgio Inghirami, Mario Boccadoro, Alessandro Pileri

Research output: Contribution to journalArticlepeer-review

Abstract

N- and K-ras oncogene mutations represent the most frequent molecular lesions in plasma cell dyscrasias. They are not randomly distributed since they are detectable in multiple myeloma (MM) (9-31% and plasma cell leukemia (PCL) (30% and not in monoclonal gammopathy of undetermined significance (MGUS) and solitary plasmacytoma (SP). Codons 12, 13 and 61 of N- and K-ras genes have been found mutated. Mutations affecting codon 61 of N-ras gene are the most frequent finding. A heterogeneous pattern of mutations is described with a prevalence of purine-pyrimidine trans versions. Ras gene mutations have been predominantly detected in myelomas characterized by an advanced stage disease, and adverse prognostic parameters. These findings suggest that ras mutations represent a late molecular lesion and may be implicated in tumor progression rather than tumor initiation.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalLeukemia and Lymphoma
Volume15
Issue number1-2
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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