N-glycomic biomarkers of biological aging and longevity: A link with inflammaging

Fabio Dall'Olio, Valerie Vanhooren, Cuiying Chitty Chen, P. Eline Slagboom, Manfred Wuhrer, Claudio Franceschi

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Glycosylation is a frequent co/post-translational modification of proteins which modulates a variety of biological functions. The analysis of N-glycome, i.e. the sugar chains N-linked to asparagine, identified new candidate biomarkers of aging such as N-glycans devoid of galactose residues on their branches, in a variety of human and experimental model systems, such as healthy old people, centenarians and their offspring and caloric restricted mice. These agalactosylated biantennary structures mainly decorate Asn297 of Fc portion of IgG (IgG-G0), and are present also in patients affected by progeroid syndromes and a variety of autoimmune/inflammatory diseases. IgG-G0 exert a pro-inflammatory effect through different mechanisms, including the lectin pathway of complement, binding to Fcγ receptors and formation of autoantibody aggregates. The age-related accumulation of IgG-G0 can contribute to inflammaging, the low-grade pro-inflammatory status that characterizes elderly, by creating a vicious loop in which inflammation is responsible for the production of aberrantly glycosylated IgG which, in turn, would activate the immune system, exacerbating inflammation. Moreover, recent data suggest that the N-glycomic shift observed in aging could be related not only to inflammation but also to alteration of important metabolic pathways. Thus, altered N-glycans are both powerful markers of aging and possible contributors to its pathogenesis.

Original languageEnglish
Pages (from-to)685-698
Number of pages14
JournalAgeing Research Reviews
Volume12
Issue number2
DOIs
Publication statusPublished - Mar 2013

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Glycomics
Biomarkers
Immunoglobulin G
Aging of materials
Inflammation
Translational Protein Modification
Polysaccharides
Mannose-Binding Lectin Complement Pathway
Glycosylation
Fc Receptors
Immune system
Asparagine
Post Translational Protein Processing
Metabolic Networks and Pathways
Galactose
Lectins
Sugars
Autoantibodies
Autoimmune Diseases
Immune System

Keywords

  • Antibody glycosylation
  • Autoimmune disease
  • Glycosylation
  • High-throughput glycomic analysis
  • Inflammaging
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology

Cite this

N-glycomic biomarkers of biological aging and longevity : A link with inflammaging. / Dall'Olio, Fabio; Vanhooren, Valerie; Chen, Cuiying Chitty; Slagboom, P. Eline; Wuhrer, Manfred; Franceschi, Claudio.

In: Ageing Research Reviews, Vol. 12, No. 2, 03.2013, p. 685-698.

Research output: Contribution to journalArticle

Dall'Olio, Fabio ; Vanhooren, Valerie ; Chen, Cuiying Chitty ; Slagboom, P. Eline ; Wuhrer, Manfred ; Franceschi, Claudio. / N-glycomic biomarkers of biological aging and longevity : A link with inflammaging. In: Ageing Research Reviews. 2013 ; Vol. 12, No. 2. pp. 685-698.
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