N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression

Carmela Saturnino, Ines Barone, Domenico Iacopetta, Annaluisa Mariconda, Maria Stefania Sinicropi, Camillo Rosano, Antonella Campana, Stefania Catalano, Pasquale Longo, Sebastiano Andò

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim: Metal carbenic complexes have received considerable attention in both the catalysis and biological fields for their potential applications in cancer and antimicrobial therapies. Results: A small series of new silver and gold N-heterocyclic carbene complexes has been designed and synthesized. Among the tested complexes, one compound was particularly active in inhibiting anchorage-dependent and -independent breast cancer proliferation, and inducing cell apoptosis via a mitochondria-related process. The antitumor activity was associated to the transcriptional activation of the tumor suppressor gene p53 in an Sp1-dependent manner, as evidenced by biological and docking studies. Conclusion: Our results highlight the importance and the versatility of N-heterocyclic carbene complexes of gold and silver as useful tools against breast cancer progression.

Original languageEnglish
Pages (from-to)2213-2229
Number of pages17
JournalFuture Medicinal Chemistry
Volume8
Issue number18
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Silver
Gold
Breast Neoplasms
Coordination Complexes
Tumor Suppressor Genes
Catalysis
Transcriptional Activation
Mitochondria
Cell Proliferation
Apoptosis
Neoplasms
carbene
Therapeutics

Keywords

  • breast cancer
  • mitochondria
  • N-heterocyclic carbene complexes
  • p53
  • Sp1
  • transmetallation

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Saturnino, C., Barone, I., Iacopetta, D., Mariconda, A., Sinicropi, M. S., Rosano, C., ... Andò, S. (2016). N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression. Future Medicinal Chemistry, 8(18), 2213-2229. https://doi.org/10.4155/fmc-2016-0160

N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression. / Saturnino, Carmela; Barone, Ines; Iacopetta, Domenico; Mariconda, Annaluisa; Sinicropi, Maria Stefania; Rosano, Camillo; Campana, Antonella; Catalano, Stefania; Longo, Pasquale; Andò, Sebastiano.

In: Future Medicinal Chemistry, Vol. 8, No. 18, 01.12.2016, p. 2213-2229.

Research output: Contribution to journalArticle

Saturnino, C, Barone, I, Iacopetta, D, Mariconda, A, Sinicropi, MS, Rosano, C, Campana, A, Catalano, S, Longo, P & Andò, S 2016, 'N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression', Future Medicinal Chemistry, vol. 8, no. 18, pp. 2213-2229. https://doi.org/10.4155/fmc-2016-0160
Saturnino, Carmela ; Barone, Ines ; Iacopetta, Domenico ; Mariconda, Annaluisa ; Sinicropi, Maria Stefania ; Rosano, Camillo ; Campana, Antonella ; Catalano, Stefania ; Longo, Pasquale ; Andò, Sebastiano. / N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression. In: Future Medicinal Chemistry. 2016 ; Vol. 8, No. 18. pp. 2213-2229.
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