N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression

Carmela Saturnino; Ines Barone; Domenico Iacopetta; Annaluisa Mariconda; Maria Stefania Sinicropi; Camillo Rosano; Antonella Campana; Stefania Catalano; Pasquale Longo; Sebastiano Andò

doi:10.4155/fmc-2016-0160

N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression

Carmela Saturnino, Ines Barone, Domenico Iacopetta, Annaluisa Mariconda, Maria Stefania Sinicropi, Camillo Rosano, Antonella Campana, Stefania Catalano, Pasquale Longo, Sebastiano Andò

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article

Abstract

Aim: Metal carbenic complexes have received considerable attention in both the catalysis and biological fields for their potential applications in cancer and antimicrobial therapies. Results: A small series of new silver and gold N-heterocyclic carbene complexes has been designed and synthesized. Among the tested complexes, one compound was particularly active in inhibiting anchorage-dependent and -independent breast cancer proliferation, and inducing cell apoptosis via a mitochondria-related process. The antitumor activity was associated to the transcriptional activation of the tumor suppressor gene p53 in an Sp1-dependent manner, as evidenced by biological and docking studies. Conclusion: Our results highlight the importance and the versatility of N-heterocyclic carbene complexes of gold and silver as useful tools against breast cancer progression.

Original language	English
Pages (from-to)	2213-2229
Number of pages	17
Journal	Future Medicinal Chemistry
Volume	8
Issue number	18
DOIs	https://doi.org/10.4155/fmc-2016-0160
Publication status	Published - Dec 1 2016

Fingerprint

Keywords

breast cancer
mitochondria
N-heterocyclic carbene complexes
p53
Sp1
transmetallation

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

Cite this

Saturnino, C., Barone, I., Iacopetta, D., Mariconda, A., Sinicropi, M. S., Rosano, C., Campana, A., Catalano, S., Longo, P., & Andò, S. (2016). N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression. Future Medicinal Chemistry, 8(18), 2213-2229. https://doi.org/10.4155/fmc-2016-0160

N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression. / Saturnino, Carmela; Barone, Ines; Iacopetta, Domenico; Mariconda, Annaluisa; Sinicropi, Maria Stefania; Rosano, Camillo; Campana, Antonella; Catalano, Stefania; Longo, Pasquale; Andò, Sebastiano.

In: Future Medicinal Chemistry, Vol. 8, No. 18, 01.12.2016, p. 2213-2229.

Research output: Contribution to journal › Article

Saturnino, Carmela ; Barone, Ines ; Iacopetta, Domenico ; Mariconda, Annaluisa ; Sinicropi, Maria Stefania ; Rosano, Camillo ; Campana, Antonella ; Catalano, Stefania ; Longo, Pasquale ; Andò, Sebastiano. / N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression. In: Future Medicinal Chemistry. 2016 ; Vol. 8, No. 18. pp. 2213-2229.

@article{c04e386bff9841889e6bed77435668f7,

title = "N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression",

abstract = "Aim: Metal carbenic complexes have received considerable attention in both the catalysis and biological fields for their potential applications in cancer and antimicrobial therapies. Results: A small series of new silver and gold N-heterocyclic carbene complexes has been designed and synthesized. Among the tested complexes, one compound was particularly active in inhibiting anchorage-dependent and -independent breast cancer proliferation, and inducing cell apoptosis via a mitochondria-related process. The antitumor activity was associated to the transcriptional activation of the tumor suppressor gene p53 in an Sp1-dependent manner, as evidenced by biological and docking studies. Conclusion: Our results highlight the importance and the versatility of N-heterocyclic carbene complexes of gold and silver as useful tools against breast cancer progression.",

keywords = "breast cancer, mitochondria, N-heterocyclic carbene complexes, p53, Sp1, transmetallation",

author = "Carmela Saturnino and Ines Barone and Domenico Iacopetta and Annaluisa Mariconda and Sinicropi, {Maria Stefania} and Camillo Rosano and Antonella Campana and Stefania Catalano and Pasquale Longo and Sebastiano And{\`o}",

year = "2016",

month = dec

day = "1",

doi = "10.4155/fmc-2016-0160",

language = "English",

volume = "8",

pages = "2213--2229",

journal = "Future Medicinal Chemistry",

issn = "1756-8919",

publisher = "Future Science",

number = "18",

}

TY - JOUR

T1 - N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression

AU - Saturnino, Carmela

AU - Barone, Ines

AU - Iacopetta, Domenico

AU - Mariconda, Annaluisa

AU - Sinicropi, Maria Stefania

AU - Rosano, Camillo

AU - Campana, Antonella

AU - Catalano, Stefania

AU - Longo, Pasquale

AU - Andò, Sebastiano

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Aim: Metal carbenic complexes have received considerable attention in both the catalysis and biological fields for their potential applications in cancer and antimicrobial therapies. Results: A small series of new silver and gold N-heterocyclic carbene complexes has been designed and synthesized. Among the tested complexes, one compound was particularly active in inhibiting anchorage-dependent and -independent breast cancer proliferation, and inducing cell apoptosis via a mitochondria-related process. The antitumor activity was associated to the transcriptional activation of the tumor suppressor gene p53 in an Sp1-dependent manner, as evidenced by biological and docking studies. Conclusion: Our results highlight the importance and the versatility of N-heterocyclic carbene complexes of gold and silver as useful tools against breast cancer progression.

AB - Aim: Metal carbenic complexes have received considerable attention in both the catalysis and biological fields for their potential applications in cancer and antimicrobial therapies. Results: A small series of new silver and gold N-heterocyclic carbene complexes has been designed and synthesized. Among the tested complexes, one compound was particularly active in inhibiting anchorage-dependent and -independent breast cancer proliferation, and inducing cell apoptosis via a mitochondria-related process. The antitumor activity was associated to the transcriptional activation of the tumor suppressor gene p53 in an Sp1-dependent manner, as evidenced by biological and docking studies. Conclusion: Our results highlight the importance and the versatility of N-heterocyclic carbene complexes of gold and silver as useful tools against breast cancer progression.

KW - breast cancer

KW - mitochondria

KW - N-heterocyclic carbene complexes

KW - p53

KW - Sp1

KW - transmetallation

UR - http://www.scopus.com/inward/record.url?scp=84999287074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84999287074&partnerID=8YFLogxK

U2 - 10.4155/fmc-2016-0160

DO - 10.4155/fmc-2016-0160

M3 - Article

AN - SCOPUS:84999287074

VL - 8

SP - 2213

EP - 2229

JO - Future Medicinal Chemistry

JF - Future Medicinal Chemistry

SN - 1756-8919

IS - 18

ER -

Access to Document

10.4155/fmc-2016-0160