n-Hexane-induced Parkinsonism: Pathogenetic hypotheses

G. Pezzoli; A. Antonini; S. Barbieri; M. Canesi; L. Perbellini; A. Zecchinelli; C. B. Mariani; A. Bonetti; K. L. Leenders

doi:10.1002/mds.870100308

n-Hexane-induced Parkinsonism: Pathogenetic hypotheses

G. Pezzoli, A. Antonini, S. Barbieri, M. Canesi, L. Perbellini, A. Zecchinelli, C. B. Mariani, A. Bonetti, K. L. Leenders

Research output: Contribution to journal › Article › peer-review

Abstract

n-Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by-products of lipid peroxidation, and they may have a nigrotoxic effect like that of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n-hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.

Original language	English
Pages (from-to)	279-282
Number of pages	4
Journal	Movement Disorders
Volume	10
Issue number	3
DOIs	https://doi.org/10.1002/mds.870100308
Publication status	Published - 1995

Keywords

2,5-Hexanedione
Hydrocarbons
Lipid peroxidation
n-Hexane
Parkinson's disease
Positron emission tomography

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1002/mds.870100308

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title = "n-Hexane-induced Parkinsonism: Pathogenetic hypotheses",

abstract = "n-Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by-products of lipid peroxidation, and they may have a nigrotoxic effect like that of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n-hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.",

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T1 - n-Hexane-induced Parkinsonism

T2 - Pathogenetic hypotheses

AU - Pezzoli, G.

AU - Antonini, A.

AU - Barbieri, S.

AU - Canesi, M.

AU - Perbellini, L.

AU - Zecchinelli, A.

AU - Mariani, C. B.

AU - Bonetti, A.

AU - Leenders, K. L.

PY - 1995

Y1 - 1995

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AB - n-Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by-products of lipid peroxidation, and they may have a nigrotoxic effect like that of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n-hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.

KW - 2,5-Hexanedione

KW - Hydrocarbons

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KW - n-Hexane

KW - Parkinson's disease

KW - Positron emission tomography

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