n-Hexane-induced Parkinsonism: Pathogenetic hypotheses

G. Pezzoli, A. Antonini, S. Barbieri, M. Canesi, L. Perbellini, A. Zecchinelli, C. B. Mariani, A. Bonetti, K. L. Leenders

Research output: Contribution to journalArticlepeer-review


n-Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by-products of lipid peroxidation, and they may have a nigrotoxic effect like that of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n-hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalMovement Disorders
Issue number3
Publication statusPublished - 1995


  • 2,5-Hexanedione
  • Hydrocarbons
  • Lipid peroxidation
  • n-Hexane
  • Parkinson's disease
  • Positron emission tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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