N-methyl-d-aspartate neurotoxicity in hippocampal slices: protection by aniracetam

Marina Pizzi, Ornella Consolandi, Maurizio Memo, PierFranco Spano

Research output: Contribution to journalArticlepeer-review

Abstract

Aniracetam, a drug known to elicit cognition enhancing properties in both animals and humans, was found to counteract the neurotoxicity induced by excitatory amino acids in primary cultures of cerebellar neurons. We report here that aniracetam prevents the neurotoxic effect induced by N-methyl-d-aspartate (NMDA) in rat hippocampal slices. Time-course experiments showed that the aniracetam-induced neuroprotection does not require preincubation of the slices with the drug. Maximal effective concentration of aniracetam was 10 μM. Since the NMDA-mediated cell death in hippocampal slices is considered a valuable experimental model of ischemia, these results suggest a possible novel therapeutic application for aniracetam.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalEuropean Journal of Pharmacology
Volume275
Issue number3
DOIs
Publication statusPublished - Mar 14 1995

Keywords

  • Aniracetam
  • Hippocampus
  • NMDA (N-methyl-d-aspartate)

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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