TY - JOUR
T1 - N-methyl-d-aspartate neurotoxicity in hippocampal slices
T2 - protection by aniracetam
AU - Pizzi, Marina
AU - Consolandi, Ornella
AU - Memo, Maurizio
AU - Spano, PierFranco
PY - 1995/3/14
Y1 - 1995/3/14
N2 - Aniracetam, a drug known to elicit cognition enhancing properties in both animals and humans, was found to counteract the neurotoxicity induced by excitatory amino acids in primary cultures of cerebellar neurons. We report here that aniracetam prevents the neurotoxic effect induced by N-methyl-d-aspartate (NMDA) in rat hippocampal slices. Time-course experiments showed that the aniracetam-induced neuroprotection does not require preincubation of the slices with the drug. Maximal effective concentration of aniracetam was 10 μM. Since the NMDA-mediated cell death in hippocampal slices is considered a valuable experimental model of ischemia, these results suggest a possible novel therapeutic application for aniracetam.
AB - Aniracetam, a drug known to elicit cognition enhancing properties in both animals and humans, was found to counteract the neurotoxicity induced by excitatory amino acids in primary cultures of cerebellar neurons. We report here that aniracetam prevents the neurotoxic effect induced by N-methyl-d-aspartate (NMDA) in rat hippocampal slices. Time-course experiments showed that the aniracetam-induced neuroprotection does not require preincubation of the slices with the drug. Maximal effective concentration of aniracetam was 10 μM. Since the NMDA-mediated cell death in hippocampal slices is considered a valuable experimental model of ischemia, these results suggest a possible novel therapeutic application for aniracetam.
KW - Aniracetam
KW - Hippocampus
KW - NMDA (N-methyl-d-aspartate)
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U2 - 10.1016/0014-2999(95)00047-O
DO - 10.1016/0014-2999(95)00047-O
M3 - Article
C2 - 7768301
AN - SCOPUS:0028899722
VL - 275
SP - 311
EP - 314
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -