N-methylformamide affects spontaneous metastases of 3LL lines and increases natural killer activity of tumor-bearing mice

C. Greco, D. Del Bufalo, D. Giannarelli, M. Marangolo, M. P. Fuggetta, E. Bonmassar, G. Zupi

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Abstract

The antitumor activity of the polar solvent N-methylformamide (NMF) was evaluated on three lines derived from the Lewis lung carcinoma (3 LL), endowed with different metastatic potential. Two administration schedules were tested, these being repeated regimens of NM F (200 mg/kg per dose) for 12 consecutive days, starting 24 h or 6-10 days after tumor implantation (early or late treatment, respectively). The results of the present work can be summarized as follows: (1) NMF regimens did not greatly affect tumor growth behavior of 3LL lines; conversely, they markedly influenced their spontaneous colonizing ability in the lungs, either by delaying early metastatic spread or by reducing the number and size of pulmonary metastases already implanted. (2) A significant increase of NK cell activity during and after early treatment with NMF was observed in the more-metastasizing lines, thus suggesting the possibility of an immunomodulating effect of NMF.

Original languageEnglish
Pages (from-to)153-163
Number of pages11
JournalClinical & Experimental Metastasis
Volume8
Issue number2
DOIs
Publication statusPublished - Mar 1990

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methylformamide
Population Growth
Neoplasm Metastasis
Neoplasms
Lewis Lung Carcinoma
Lung
Natural Killer Cells
Appointments and Schedules
Growth

ASJC Scopus subject areas

  • Cancer Research

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N-methylformamide affects spontaneous metastases of 3LL lines and increases natural killer activity of tumor-bearing mice. / Greco, C.; Del Bufalo, D.; Giannarelli, D.; Marangolo, M.; Fuggetta, M. P.; Bonmassar, E.; Zupi, G.

In: Clinical & Experimental Metastasis, Vol. 8, No. 2, 03.1990, p. 153-163.

Research output: Contribution to journalArticle

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abstract = "The antitumor activity of the polar solvent N-methylformamide (NMF) was evaluated on three lines derived from the Lewis lung carcinoma (3 LL), endowed with different metastatic potential. Two administration schedules were tested, these being repeated regimens of NM F (200 mg/kg per dose) for 12 consecutive days, starting 24 h or 6-10 days after tumor implantation (early or late treatment, respectively). The results of the present work can be summarized as follows: (1) NMF regimens did not greatly affect tumor growth behavior of 3LL lines; conversely, they markedly influenced their spontaneous colonizing ability in the lungs, either by delaying early metastatic spread or by reducing the number and size of pulmonary metastases already implanted. (2) A significant increase of NK cell activity during and after early treatment with NMF was observed in the more-metastasizing lines, thus suggesting the possibility of an immunomodulating effect of NMF.",
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AU - Del Bufalo, D.

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AU - Marangolo, M.

AU - Fuggetta, M. P.

AU - Bonmassar, E.

AU - Zupi, G.

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AB - The antitumor activity of the polar solvent N-methylformamide (NMF) was evaluated on three lines derived from the Lewis lung carcinoma (3 LL), endowed with different metastatic potential. Two administration schedules were tested, these being repeated regimens of NM F (200 mg/kg per dose) for 12 consecutive days, starting 24 h or 6-10 days after tumor implantation (early or late treatment, respectively). The results of the present work can be summarized as follows: (1) NMF regimens did not greatly affect tumor growth behavior of 3LL lines; conversely, they markedly influenced their spontaneous colonizing ability in the lungs, either by delaying early metastatic spread or by reducing the number and size of pulmonary metastases already implanted. (2) A significant increase of NK cell activity during and after early treatment with NMF was observed in the more-metastasizing lines, thus suggesting the possibility of an immunomodulating effect of NMF.

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