N-myc activation by proviral insertion in MCF 247-induced murine T-cell lymphomas

R. Dolcetti, S. Rizzo, A. Viel, R. Maestro, V. De Re, G. Feriotto, M. Boiocchi

Research output: Contribution to journalArticlepeer-review

Abstract

N-myc proto-oncogene rearrangement was found in three out of six AKR murine T-cell lymphomas induced by the highly oncogenic MCF 247 MuLV. Molecular analyses showed that structural modification of the proto-oncogene in all three lymphomas was in the consequence of MCF 247 proviral integration within the gene III exon. All integrated proviruses have the same transcriptional orientation as the N-myc gene. As a consequence of proviral insertion, the N-myc gene becomes transcriptionally active, producing an abnormal mRNA. These findings suggest a possible role of such an integrative event in murine T-cell lymphomagenesis.

Original languageEnglish
Pages (from-to)1009-1014
Number of pages6
JournalOncogene
Volume4
Issue number8
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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