A continuous series of 51 Neuroblastoma (Nb) cases has been studied by analyzing N-myc amplification and other clinical and biochemical variables. The prognostic value of N-myc amplification does not appear as strong in this as in other studies. In addition, N-myc amplification was less frequent in advanced Nb cases than previously reported and it appeared loosely associated with clinical (Evans) staging. By contrast, N-myc amplification was strongly associated with less differentiated histology and with large size of the primary tumors, at least in elder children (aged > 1 year at onset). Among tumor markers analyzed, low levels of urinary vanilyl-mandelic acid (VMA) and high levels of serum activities of neuron-specific enolase (NSE) and lactic dehydrogenase (LDH) were significantly associated with N-myc amplification in elder children, while such correlations were reversed in infants.
|Number of pages||6|
|Journal||Clinical Chemistry and Enzymology Communications|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Clinical Biochemistry