N-myc amplification and its correlations with prognosis and with other bio-clinical markers in neuroblastoma fresh tumors

R. Sansone, P. Strigini, V. Fontana, D. Di Martino, P. Cornaglia-Ferraris, G. P. Tonini, E. Lanino, B. De Bernardi, N. Marchese

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Abstract

A continuous series of 51 Neuroblastoma (Nb) cases has been studied by analyzing N-myc amplification and other clinical and biochemical variables. The prognostic value of N-myc amplification does not appear as strong in this as in other studies. In addition, N-myc amplification was less frequent in advanced Nb cases than previously reported and it appeared loosely associated with clinical (Evans) staging. By contrast, N-myc amplification was strongly associated with less differentiated histology and with large size of the primary tumors, at least in elder children (aged > 1 year at onset). Among tumor markers analyzed, low levels of urinary vanilyl-mandelic acid (VMA) and high levels of serum activities of neuron-specific enolase (NSE) and lactic dehydrogenase (LDH) were significantly associated with N-myc amplification in elder children, while such correlations were reversed in infants.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalClinical Chemistry and Enzymology Communications
Volume2
Issue number4-6
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Sansone, R., Strigini, P., Fontana, V., Di Martino, D., Cornaglia-Ferraris, P., Tonini, G. P., Lanino, E., De Bernardi, B., & Marchese, N. (1990). N-myc amplification and its correlations with prognosis and with other bio-clinical markers in neuroblastoma fresh tumors. Clinical Chemistry and Enzymology Communications, 2(4-6), 221-226.