N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma)

Giovanna Fabbretti, Cristina Valenti, Massimo Loda, Massimo Brisigotti, Cleto Cozzutto, Gian Paolo Tonini, Francesco Callea

Research output: Contribution to journalArticlepeer-review


Using nucleic acid analysis and in situ hybridization we have demonstrated N-myc amplification and expression in two children with a localized (stages I and II) stroma-rich neuroblastoma (NB) (ganglioneuroblastoma). The phenomenon was observed in both undifferentiated and mature ganglion-like cells. The two children are alive and disease-free without any treatment after 16 and 17 months. These observations suggest that morphologic differentiation in NB in vivo is not necessarily followed by a decrease in N-myc expression. Moreover, N-myc amplification does not represent an adverse prognostic factor. In contrast with what happens in undifferentiated NB, N-myc amplification does not have an adverse effect on prognosis when occurring in localized (stages I and II), stroma-rich NB with a favorable histology.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalHuman Pathology
Issue number3
Publication statusPublished - 1993


  • gene amplification
  • gene expression
  • histology
  • hybridization
  • N-myc oncogene
  • neuroblastoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma)'. Together they form a unique fingerprint.

Cite this