Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF β-endorphin (β-EP) levels was found, while ACTH and β-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with β-EP activities in CNS is discussed.
|Number of pages||6|
|Journal||Acta Neurologica Scandinavica|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Clinical Neurology