N-terminal ACTH fragments increase the CSF β-EP content in Alzheimer type dementia

G. Nappi, F. Facchinetti, E. Martignoni, F. Petraglia, E. Sinforiani, G. Bono, A. R. Genazzani

Research output: Contribution to journalArticle

Abstract

Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF β-endorphin (β-EP) levels was found, while ACTH and β-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with β-EP activities in CNS is discussed.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalActa Neurologica Scandinavica
Volume78
Issue number2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Nappi, G., Facchinetti, F., Martignoni, E., Petraglia, F., Sinforiani, E., Bono, G., & Genazzani, A. R. (1988). N-terminal ACTH fragments increase the CSF β-EP content in Alzheimer type dementia. Acta Neurologica Scandinavica, 78(2), 146-151.