N-Terminal B-Natriuretic Peptide After Coronary Artery Bypass Graft Surgery

Giuseppe Crescenzi, Giovanni Landoni, Elena Bignami, Ilaria Belloni, Camilla Biselli, Concetta Rosica, Fabio Guarracino, Giovanni Marino, Alberto Zangrillo

Research output: Contribution to journalArticlepeer-review


Objective: To investigate N-terminal amino-acid sequence of the B-natriuretic peptide (NT-proBNP) release and its prognostic characteristics after coronary artery bypass graft surgery with and without cardiopulmonary bypass. Design: Observational study. Setting: Teaching hospital. Participants: One hundred eighty-four patients. Interventions: The authors determined plasma concentrations of NT-proBNP just before anesthesia induction and 24 hours after the end of the surgery. Measurements and Main Results: NT-proBNP concentrations (median [interquartile range]) increased from 270 (75-716) pg/mL preoperatively to 1,664 (978-3,193) pg/mL on postoperative day 1 (p <0.001), and all postoperative values were higher than the preoperative ones. NT-proBNP concentrations at day 1 were correlated to those at day 0 (r2 = 0.34, p <0.001). Patients showing elevated concentration of cTnI at day 1 (>14 ng/mL) had significantly (p = 0.04) higher plasma NT-proBNP levels than patients with a low cardiac troponin I concentration. Patients with prolonged intensive care unit (ICU) stay (>4 days) showed at day 1 significantly higher (p = 0.003) plasma NT-proBNP levels than patients with ICU stay

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number2
Publication statusPublished - Apr 2009


  • B-natriuretic peptide
  • biomarkers
  • cardiac surgery
  • troponin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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