N-TproBNP as biomarker in systemic sclerosis

Tommaso Schioppo, Carolina Artusi, Teresa Ciavarella, Francesca Ingegnoli, Antonella Murgo, Silvana Zeni, Cecilia Chighizola, Pier Luigi Meroni

Research output: Contribution to journalArticlepeer-review


Systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue fibrosis affecting the skin and internal organs, fibroproliferative vasculopathy, and autoimmune activation. SSc still heralds a poor prognosis with significant morbidity and mortality. Early detection of organ involvement is critical as currently available treatments are most effective when started early. Many candidate biomarkers have been investigated in the past two decades. However, despite the enormous efforts, no accurate tool to predict the pattern of organ involvement and to assess disease activity has been yet identified. The N-terminal fragment of probrain natriuretic peptide (N-TproBNP) is a neurohormone released by ventricular myocytes in response to pressure overload. N-TproBNP is highly relevant for diagnosis, prognosis, and prediction of pulmonary arterial hypertension in SSc. Moreover, several studies support its potential benefit for cardiac assessment of scleroderma patients. Conversely, the role of N-TproBNP as surrogate marker of pulmonary fibrosis and skin involvement is much less clear.We provide an extensive review of the studies that have previously investigated the role of N-TproBNP as candidate biomarker in scleroderma manifestations, presenting also the findings of a recent study we conducted in a cohort of 87 SSc patients.

Original languageEnglish
Pages (from-to)292-301
Number of pages10
JournalClinical Reviews in Allergy and Immunology
Issue number3
Publication statusPublished - Dec 2012


  • Biomarker
  • Interstitial lung disease
  • N-TproBNP
  • Pulmonary arterial hypertension
  • Systemic sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy


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