Abstract
Systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue fibrosis affecting the skin and internal organs, fibroproliferative vasculopathy, and autoimmune activation. SSc still heralds a poor prognosis with significant morbidity and mortality. Early detection of organ involvement is critical as currently available treatments are most effective when started early. Many candidate biomarkers have been investigated in the past two decades. However, despite the enormous efforts, no accurate tool to predict the pattern of organ involvement and to assess disease activity has been yet identified. The N-terminal fragment of probrain natriuretic peptide (N-TproBNP) is a neurohormone released by ventricular myocytes in response to pressure overload. N-TproBNP is highly relevant for diagnosis, prognosis, and prediction of pulmonary arterial hypertension in SSc. Moreover, several studies support its potential benefit for cardiac assessment of scleroderma patients. Conversely, the role of N-TproBNP as surrogate marker of pulmonary fibrosis and skin involvement is much less clear.We provide an extensive review of the studies that have previously investigated the role of N-TproBNP as candidate biomarker in scleroderma manifestations, presenting also the findings of a recent study we conducted in a cohort of 87 SSc patients.
| Original language | English |
|---|---|
| Pages (from-to) | 292-301 |
| Number of pages | 10 |
| Journal | Clinical Reviews in Allergy and Immunology |
| Volume | 43 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 2012 |
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Keywords
- Biomarker
- Interstitial lung disease
- N-TproBNP
- Pulmonary arterial hypertension
- Systemic sclerosis
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
N-TproBNP as biomarker in systemic sclerosis. / Schioppo, Tommaso; Artusi, Carolina; Ciavarella, Teresa; Ingegnoli, Francesca; Murgo, Antonella; Zeni, Silvana; Chighizola, Cecilia; Meroni, Pier Luigi.
In: Clinical Reviews in Allergy and Immunology, Vol. 43, No. 3, 12.2012, p. 292-301.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - N-TproBNP as biomarker in systemic sclerosis
AU - Schioppo, Tommaso
AU - Artusi, Carolina
AU - Ciavarella, Teresa
AU - Ingegnoli, Francesca
AU - Murgo, Antonella
AU - Zeni, Silvana
AU - Chighizola, Cecilia
AU - Meroni, Pier Luigi
PY - 2012/12
Y1 - 2012/12
N2 - Systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue fibrosis affecting the skin and internal organs, fibroproliferative vasculopathy, and autoimmune activation. SSc still heralds a poor prognosis with significant morbidity and mortality. Early detection of organ involvement is critical as currently available treatments are most effective when started early. Many candidate biomarkers have been investigated in the past two decades. However, despite the enormous efforts, no accurate tool to predict the pattern of organ involvement and to assess disease activity has been yet identified. The N-terminal fragment of probrain natriuretic peptide (N-TproBNP) is a neurohormone released by ventricular myocytes in response to pressure overload. N-TproBNP is highly relevant for diagnosis, prognosis, and prediction of pulmonary arterial hypertension in SSc. Moreover, several studies support its potential benefit for cardiac assessment of scleroderma patients. Conversely, the role of N-TproBNP as surrogate marker of pulmonary fibrosis and skin involvement is much less clear.We provide an extensive review of the studies that have previously investigated the role of N-TproBNP as candidate biomarker in scleroderma manifestations, presenting also the findings of a recent study we conducted in a cohort of 87 SSc patients.
AB - Systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue fibrosis affecting the skin and internal organs, fibroproliferative vasculopathy, and autoimmune activation. SSc still heralds a poor prognosis with significant morbidity and mortality. Early detection of organ involvement is critical as currently available treatments are most effective when started early. Many candidate biomarkers have been investigated in the past two decades. However, despite the enormous efforts, no accurate tool to predict the pattern of organ involvement and to assess disease activity has been yet identified. The N-terminal fragment of probrain natriuretic peptide (N-TproBNP) is a neurohormone released by ventricular myocytes in response to pressure overload. N-TproBNP is highly relevant for diagnosis, prognosis, and prediction of pulmonary arterial hypertension in SSc. Moreover, several studies support its potential benefit for cardiac assessment of scleroderma patients. Conversely, the role of N-TproBNP as surrogate marker of pulmonary fibrosis and skin involvement is much less clear.We provide an extensive review of the studies that have previously investigated the role of N-TproBNP as candidate biomarker in scleroderma manifestations, presenting also the findings of a recent study we conducted in a cohort of 87 SSc patients.
KW - Biomarker
KW - Interstitial lung disease
KW - N-TproBNP
KW - Pulmonary arterial hypertension
KW - Systemic sclerosis
UR - http://www.scopus.com/inward/record.url?scp=84871660172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871660172&partnerID=8YFLogxK
U2 - 10.1007/s12016-012-8312-4
DO - 10.1007/s12016-012-8312-4
M3 - Article
C2 - 22669751
AN - SCOPUS:84871660172
VL - 43
SP - 292
EP - 301
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
SN - 1080-0549
IS - 3
ER -