N1 methylnicotinamide excretion and affective disorders

C. L. Cazzullo, E. Sacchetti, E. Smeraldi

Research output: Contribution to journalArticlepeer-review


N1 Methylnicotinamide urinary output is examined in 38 healthy volunteers, 52 patients with secondary affective disorders (SAD), 55 patients with primary affective disorders (PAD) and 46 healthy first degree relatives of PAD patients. The results indicate that in PAD patients and their first degree relatives the frequency of low N1 MN excretion was significantly higher than in healthy controls and in patients with secondary affective disorders, and that PAD patients have a consistently low N1 MN output, at all times constant and independent of the clinical phases of the disease. These findings provide evidence that the low N1 MN levels may represent an index of a biological background linked to a high morbidity risk for primary affective disorders. The theoretical implications deriving from these data are briefly discussed.

Original languageEnglish
Pages (from-to)265-270
Number of pages6
JournalPsychological Medicine
Issue number2
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology


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