N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease

A pharmacological study

R. Traversa, M. Pierantozzi, R. Semprini, M. Loberti, M. C. Cicardi, A. Bassi, P. Stanzione

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalJournal of Neural Transmission, Supplement
Issue number45
Publication statusPublished - 1995

Fingerprint

Somatosensory Evoked Potentials
Median Nerve
Parkinson Disease
Apomorphine
Pharmacology
Dihydroxyphenylalanine
Haloperidol
Antipsychotic Agents
Oral Administration
Research Design
Therapeutics
Age Groups

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Traversa, R., Pierantozzi, M., Semprini, R., Loberti, M., Cicardi, M. C., Bassi, A., & Stanzione, P. (1995). N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease: A pharmacological study. Journal of Neural Transmission, Supplement, (45), 177-185.

N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease : A pharmacological study. / Traversa, R.; Pierantozzi, M.; Semprini, R.; Loberti, M.; Cicardi, M. C.; Bassi, A.; Stanzione, P.

In: Journal of Neural Transmission, Supplement, No. 45, 1995, p. 177-185.

Research output: Contribution to journalArticle

Traversa, R, Pierantozzi, M, Semprini, R, Loberti, M, Cicardi, MC, Bassi, A & Stanzione, P 1995, 'N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease: A pharmacological study', Journal of Neural Transmission, Supplement, no. 45, pp. 177-185.
Traversa, R. ; Pierantozzi, M. ; Semprini, R. ; Loberti, M. ; Cicardi, M. C. ; Bassi, A. ; Stanzione, P. / N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease : A pharmacological study. In: Journal of Neural Transmission, Supplement. 1995 ; No. 45. pp. 177-185.
@article{0027084f339e4424bdb33f6a5c9b6676,
title = "N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease: A pharmacological study",
abstract = "We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.",
author = "R. Traversa and M. Pierantozzi and R. Semprini and M. Loberti and Cicardi, {M. C.} and A. Bassi and P. Stanzione",
year = "1995",
language = "English",
pages = "177--185",
journal = "Journal of Neural Transmission, Supplement",
issn = "0303-6995",
publisher = "Springer Wien",
number = "45",

}

TY - JOUR

T1 - N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease

T2 - A pharmacological study

AU - Traversa, R.

AU - Pierantozzi, M.

AU - Semprini, R.

AU - Loberti, M.

AU - Cicardi, M. C.

AU - Bassi, A.

AU - Stanzione, P.

PY - 1995

Y1 - 1995

N2 - We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.

AB - We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0028971350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028971350&partnerID=8YFLogxK

M3 - Article

SP - 177

EP - 185

JO - Journal of Neural Transmission, Supplement

JF - Journal of Neural Transmission, Supplement

SN - 0303-6995

IS - 45

ER -