Abstract
We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 177-185 |
| Number of pages | 9 |
| Journal | Journal of Neural Transmission, Supplement |
| Issue number | 45 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Neuroscience(all)
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N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease : A pharmacological study. / Traversa, R.; Pierantozzi, M.; Semprini, R.; Loberti, M.; Cicardi, M. C.; Bassi, A.; Stanzione, P.
In: Journal of Neural Transmission, Supplement, No. 45, 1995, p. 177-185.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease
T2 - A pharmacological study
AU - Traversa, R.
AU - Pierantozzi, M.
AU - Semprini, R.
AU - Loberti, M.
AU - Cicardi, M. C.
AU - Bassi, A.
AU - Stanzione, P.
PY - 1995
Y1 - 1995
N2 - We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.
AB - We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0028971350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028971350&partnerID=8YFLogxK
M3 - Article
SP - 177
EP - 185
JO - Journal of Neural Transmission, Supplement
JF - Journal of Neural Transmission, Supplement
SN - 0303-6995
IS - 45
ER -