TY - JOUR
T1 - N30 wave amplitude of Somatosensory Evoked Potentials from median nerve in Parkinson's disease
T2 - A pharmacological study
AU - Traversa, R.
AU - Pierantozzi, M.
AU - Semprini, R.
AU - Loberti, M.
AU - Cicardi, M. C.
AU - Bassi, A.
AU - Stanzione, P.
PY - 1995
Y1 - 1995
N2 - We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.
AB - We studied N20 and N30 waves of Somatosensory Evoked Potentials from median nerve stimulation in different pharmacological conditions. N30 wave amplitude was decreased in 33 parkinsonians without therapy in comparison with a group of age-matched normal subjects. In a group of 19 parkinsonians, N30 wave amplitude was significantly augmented during apomorphine infusion and less evidently, but still significantly, during chronic l-dopa therapy. The administration of an oral dose of haloperidol in 11 normals did not affect significantly the studied parameters. The infusion of apomorphine in 6 psychotic patients with extrapyramidal symptoms secondary to long-term treatment with neuroleptics, determined, together with a clear-cut clinical amelioration, a significant increase of N30 amplitude and N30/N20 ratio. Possible pathophysiological hypothesis of such electrophysiological modifications are discussed.
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M3 - Article
C2 - 8748624
AN - SCOPUS:0028971350
SP - 177
EP - 185
JO - Journal of Neural Transmission, Supplement
JF - Journal of Neural Transmission, Supplement
SN - 0303-6995
IS - 45
ER -