N6-Isopentenyladenosine: A potential therapeutic agent for a variety of epithelial cancers

Monica Spinola, Francesca Colombo, F. Stefania Falvella, Tommaso A. Dragani

Research output: Contribution to journalArticlepeer-review

Abstract

Isopentenyladenosine (i6A) is a product of isopentenyltransferases and, in mammals, occurs either bound to tRNA or as a free nucleoside. Sporadic reports have suggested an anticancer effect of i 6A, mostly on leukemia cells. The present analysis of 9 human epithelial cancer cell lines derived from different types of malignant tissue revealed complete suppression of clonogenic activity in 8 of the lines after exposure to i6A at a concentration of 10 μM. Mechanistic studies showed that i6A tumor suppressor activity is associated with inhibition of cell proliferation, a block in DNA synthesis and morphological changes. These results point to i6A and to its possible derivatives as a new potential class of wide-spectrum anticancer agents.

Original languageEnglish
Pages (from-to)2744-2748
Number of pages5
JournalInternational Journal of Cancer
Volume120
Issue number12
DOIs
Publication statusPublished - Jun 15 2007

Keywords

  • Cancer cell lines
  • FDPS
  • Therapy
  • TRIT1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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