Nadolol prevents the exercise-induced rise in lymphocyte beta-receptor number in borderline hypertension

Laura Terzoli, Renato Bragato, Giovanni Battista Bolla, Gastone Leonetti, Alberto Zanchetti

Research output: Contribution to journalArticlepeer-review


Thirteen borderline hypertensives were investigated at rest and during dynamic exercise, before and after therapy with nadolol (40-80 mg/day for 7-28 days), in order to evaluate regulation of the number of lymphocyte β-receptors. Systolic blood pressure and the heart rate were measured before and after 15 min of bicycle exercise, both with and without nadolol therapy; blood samples were withdrawn for adrenaline, noradrenaline and lymphocyte β -receptor determinations. Nadolol induced a significant decrease in systolic blood pressure and the heart rate at rest, while plasma catecholamines and lymphocyte β -receptors did not change significantly. Of the physiological responses to dynamic exercise (increases in systolic blood pressure, heart rate, plasma noradrenaline levels and adrenaline and lymphocyte β -receptors), only the rise in p-re- ceptors was entirely prevented, and the increase in the heart rate was significantly attenuated by nadolol. It is suggested that the lack of a rise in the number of β -receptors during exercise may contribute to the blunted exercise-induced tachycardia in patients taking nadolol.

Original languageEnglish
Pages (from-to)S46-S47
JournalJournal of Hypertension, Supplement
Publication statusPublished - 1989


  • Borderline hypertension
  • Dynamic exercise
  • Lymphocyte beta-receptors
  • Nadolol

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology


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