Nadolol prevents the exercise-induced rise in lymphocyte beta-receptor number in borderline hypertension

Laura Terzoli, Renato Bragato, Giovanni Battista Bolla, Gastone Leonetti, Alberto Zanchetti

Research output: Contribution to journalArticle

Abstract

Thirteen borderline hypertensives were investigated at rest and during dynamic exercise, before and after therapy with nadolol (40-80 mg/day for 7-28 days), in order to evaluate regulation of the number of lymphocyte β-receptors. Systolic blood pressure and the heart rate were measured before and after 15 min of bicycle exercise, both with and without nadolol therapy; blood samples were withdrawn for adrenaline, noradrenaline and lymphocyte β -receptor determinations. Nadolol induced a significant decrease in systolic blood pressure and the heart rate at rest, while plasma catecholamines and lymphocyte β -receptors did not change significantly. Of the physiological responses to dynamic exercise (increases in systolic blood pressure, heart rate, plasma noradrenaline levels and adrenaline and lymphocyte β -receptors), only the rise in p-re- ceptors was entirely prevented, and the increase in the heart rate was significantly attenuated by nadolol. It is suggested that the lack of a rise in the number of β -receptors during exercise may contribute to the blunted exercise-induced tachycardia in patients taking nadolol.

Original languageEnglish
Pages (from-to)S46-S47
JournalJournal of Hypertension, Supplement
Volume7
Publication statusPublished - 1989

Fingerprint

Nadolol
Lymphocytes
Exercise
Blood Pressure
Hypertension
Heart Rate
Epinephrine
Norepinephrine
Catecholamine Receptors
Lymphocyte Count
Tachycardia
Therapeutics

Keywords

  • Borderline hypertension
  • Dynamic exercise
  • Lymphocyte beta-receptors
  • Nadolol

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Terzoli, L., Bragato, R., Bolla, G. B., Leonetti, G., & Zanchetti, A. (1989). Nadolol prevents the exercise-induced rise in lymphocyte beta-receptor number in borderline hypertension. Journal of Hypertension, Supplement, 7, S46-S47.

Nadolol prevents the exercise-induced rise in lymphocyte beta-receptor number in borderline hypertension. / Terzoli, Laura; Bragato, Renato; Bolla, Giovanni Battista; Leonetti, Gastone; Zanchetti, Alberto.

In: Journal of Hypertension, Supplement, Vol. 7, 1989, p. S46-S47.

Research output: Contribution to journalArticle

Terzoli, L, Bragato, R, Bolla, GB, Leonetti, G & Zanchetti, A 1989, 'Nadolol prevents the exercise-induced rise in lymphocyte beta-receptor number in borderline hypertension', Journal of Hypertension, Supplement, vol. 7, pp. S46-S47.
Terzoli, Laura ; Bragato, Renato ; Bolla, Giovanni Battista ; Leonetti, Gastone ; Zanchetti, Alberto. / Nadolol prevents the exercise-induced rise in lymphocyte beta-receptor number in borderline hypertension. In: Journal of Hypertension, Supplement. 1989 ; Vol. 7. pp. S46-S47.
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