Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations

Results of a Multicenter International Study

American and European Network of Antisynthetase Syndrome Collaborative Group

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.

METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures.

RESULTS: NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP.

CONCLUSION: NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.

Original languageEnglish
JournalJournal of Rheumatology
DOIs
Publication statusE-pub ahead of print - Nov 15 2018

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Microscopic Angioscopy
Multicenter Studies
Raynaud Disease
Systemic Scleroderma
Antisynthetase syndrome
Antinuclear Antibodies
Anti-Idiotypic Antibodies
Prospective Studies

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Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations : Results of a Multicenter International Study. / American and European Network of Antisynthetase Syndrome Collaborative Group.

In: Journal of Rheumatology, 15.11.2018.

Research output: Contribution to journalArticle

@article{b0fe3e92d326457e88ddb4f410358c74,
title = "Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study",
abstract = "OBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures.RESULTS: NVC abnormalities were observed in 62.1{\%} of AS patients compared with 29.3{\%} of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3{\%}) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47{\%} of patients with SSc-like pattern had RP.CONCLUSION: NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.",
author = "{American and European Network of Antisynthetase Syndrome Collaborative Group} and Marco Sebastiani and Konstantinos Triantafyllias and Andreina Manfredi and Gonz{\'a}lez-Gay, {Miguel Angel} and Natalia Palmou-Fontana and Giulia Cassone and Ulrich Drott and Christiane Delbr{\"u}ck and Jorge Rojas-Serrano and Chiara Bertolazzi and Laura Nu{\~n}o and Margherita Giannini and Florenzo Iannone and Vicente, {Esther F} and Santos Casta{\~n}eda and Albert Selva-O'Callaghan and Araguas, {Ernesto Trallero} and Giacomo Emmi and Annamaria Iuliano and Jutta Bauhammer and Nikolaus Miehle and Simone Parisi and Lorenzo Cavagna and Veronica Codullo and Carlomaurizio Montecucco and Lopez-Longo, {Francisco Javier} and Julia Mart{\'i}nez-Barrio and Nieto-Gonz{\'a}lez, {Juan Carlos} and Silvia Vichi and Marco Confalonieri and Paola Tomietto and Raoul Bergner and Alberto Sulli and Francesco Bonella and Federica Furini and Scir{\`e}, {Carlo Alberto} and Alessandra Bortoluzzi and Christof Specker and Simone Barsotti and Rossella Neri and Marta Mosca and Marzia Caproni and Julia Weinmann-Menke and Andreas Schwarting and Vanessa Smith and Maurizio Cutolo",
year = "2018",
month = "11",
day = "15",
doi = "10.3899/jrheum.180355",
language = "English",
journal = "Journal of Rheumatology",
issn = "0315-162X",
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TY - JOUR

T1 - Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations

T2 - Results of a Multicenter International Study

AU - American and European Network of Antisynthetase Syndrome Collaborative Group

AU - Sebastiani, Marco

AU - Triantafyllias, Konstantinos

AU - Manfredi, Andreina

AU - González-Gay, Miguel Angel

AU - Palmou-Fontana, Natalia

AU - Cassone, Giulia

AU - Drott, Ulrich

AU - Delbrück, Christiane

AU - Rojas-Serrano, Jorge

AU - Bertolazzi, Chiara

AU - Nuño, Laura

AU - Giannini, Margherita

AU - Iannone, Florenzo

AU - Vicente, Esther F

AU - Castañeda, Santos

AU - Selva-O'Callaghan, Albert

AU - Araguas, Ernesto Trallero

AU - Emmi, Giacomo

AU - Iuliano, Annamaria

AU - Bauhammer, Jutta

AU - Miehle, Nikolaus

AU - Parisi, Simone

AU - Cavagna, Lorenzo

AU - Codullo, Veronica

AU - Montecucco, Carlomaurizio

AU - Lopez-Longo, Francisco Javier

AU - Martínez-Barrio, Julia

AU - Nieto-González, Juan Carlos

AU - Vichi, Silvia

AU - Confalonieri, Marco

AU - Tomietto, Paola

AU - Bergner, Raoul

AU - Sulli, Alberto

AU - Bonella, Francesco

AU - Furini, Federica

AU - Scirè, Carlo Alberto

AU - Bortoluzzi, Alessandra

AU - Specker, Christof

AU - Barsotti, Simone

AU - Neri, Rossella

AU - Mosca, Marta

AU - Caproni, Marzia

AU - Weinmann-Menke, Julia

AU - Schwarting, Andreas

AU - Smith, Vanessa

AU - Cutolo, Maurizio

PY - 2018/11/15

Y1 - 2018/11/15

N2 - OBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures.RESULTS: NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP.CONCLUSION: NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.

AB - OBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures.RESULTS: NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP.CONCLUSION: NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.

U2 - 10.3899/jrheum.180355

DO - 10.3899/jrheum.180355

M3 - Article

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

ER -