Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Francesca Ingegnoli, Ilaria Ardoino, Patrizia Boracchi, Maurizio Cutolo, Paolo Airò, Lidia P. Ananieva, Codrina Ancuta, Luis Eduardo Andrade, Radim Becvar, Alessia Benenati, Paola Caramaschi, Patricia E. Carreira, Giovanna Cuomo, Nemanja Damjanov, Oliver Distler, Rosario Foti, Serena Guiducci, Eric Hachulla, John Highton, Cristiane KayserChiara Lubatti, Marco Matucci Cerinic, Florian Meier, Pier Luigi Meroni, Carmen Marina Mihai, Ewa Morgiel, Ulf Müller-Ladner, Esthela Loyo, Vera Ortiz, Valeria Riccieri, Agneta Scheja, Simona Skacelova, Vanessa Smith, Bojana Stamenkovic, Simon Stebbings, Viktor Stoica, Alberto Sulli, Jacek Szechinski, Alan Tyndall, Gabriele Valentini, Ulrich Walker, Silvana Zeni, Maja Zlatanovic

Research output: Contribution to journalArticle

Abstract

Objective: The aims of this study were to obtain cross-sectional data on capillaroscopy in an international multi-center cohort of Systemic Sclerosis (SSc) and to investigate the frequency of the capillaroscopic patterns and their disease-phenotype associations. Methods: Data collected between June 2004 and October 2011 in the EULAR Scleroderma Trials and Research (EUSTAR) registry were examined. Patients' profiles based on clinical and laboratory data were obtained by cluster analysis and the association between profiles and capillaroscopy was investigated by multinomial logistic regression. Results: 62 of the 110 EUSTAR centers entered data on capillaroscopy in the EUSTAR database. 376 of the 2754 patients (13.65%) were classified as scleroderma pattern absent, but non-specific capillary abnormalities were noted in 55.48% of the cases. Four major patients' profiles were identified characterized by a progressive severity for skin involvement, as well as an increased number of systemic manifestations. The early and active scleroderma patterns were generally observed in patients with mild/moderate skin involvement and a low number of disease manifestations, while the late scleroderma pattern was found more frequently in the more severe forms of the disease. Conclusion: These data indicate the importance of capillaroscopy in SSc management and that capillaroscopic patterns are directly related to the extent of organ involvement.

Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalMicrovascular Research
Volume89
DOIs
Publication statusPublished - Sep 2013

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Microscopic Angioscopy
Systemic Scleroderma
Databases
Research
Skin
Cluster analysis
Cluster Analysis
Registries
Logistics
Logistic Models
Phenotype

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

Ingegnoli, F., Ardoino, I., Boracchi, P., Cutolo, M., Airò, P., Ananieva, L. P., ... Zlatanovic, M. (2013). Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database. Microvascular Research, 89, 122-128. https://doi.org/10.1016/j.mvr.2013.06.003

Nailfold capillaroscopy in systemic sclerosis : Data from the EULAR scleroderma trials and research (EUSTAR) database. / Ingegnoli, Francesca; Ardoino, Ilaria; Boracchi, Patrizia; Cutolo, Maurizio; Airò, Paolo; Ananieva, Lidia P.; Ancuta, Codrina; Andrade, Luis Eduardo; Becvar, Radim; Benenati, Alessia; Caramaschi, Paola; Carreira, Patricia E.; Cuomo, Giovanna; Damjanov, Nemanja; Distler, Oliver; Foti, Rosario; Guiducci, Serena; Hachulla, Eric; Highton, John; Kayser, Cristiane; Lubatti, Chiara; Cerinic, Marco Matucci; Meier, Florian; Meroni, Pier Luigi; Mihai, Carmen Marina; Morgiel, Ewa; Müller-Ladner, Ulf; Loyo, Esthela; Ortiz, Vera; Riccieri, Valeria; Scheja, Agneta; Skacelova, Simona; Smith, Vanessa; Stamenkovic, Bojana; Stebbings, Simon; Stoica, Viktor; Sulli, Alberto; Szechinski, Jacek; Tyndall, Alan; Valentini, Gabriele; Walker, Ulrich; Zeni, Silvana; Zlatanovic, Maja.

In: Microvascular Research, Vol. 89, 09.2013, p. 122-128.

Research output: Contribution to journalArticle

Ingegnoli, F, Ardoino, I, Boracchi, P, Cutolo, M, Airò, P, Ananieva, LP, Ancuta, C, Andrade, LE, Becvar, R, Benenati, A, Caramaschi, P, Carreira, PE, Cuomo, G, Damjanov, N, Distler, O, Foti, R, Guiducci, S, Hachulla, E, Highton, J, Kayser, C, Lubatti, C, Cerinic, MM, Meier, F, Meroni, PL, Mihai, CM, Morgiel, E, Müller-Ladner, U, Loyo, E, Ortiz, V, Riccieri, V, Scheja, A, Skacelova, S, Smith, V, Stamenkovic, B, Stebbings, S, Stoica, V, Sulli, A, Szechinski, J, Tyndall, A, Valentini, G, Walker, U, Zeni, S & Zlatanovic, M 2013, 'Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database', Microvascular Research, vol. 89, pp. 122-128. https://doi.org/10.1016/j.mvr.2013.06.003
Ingegnoli, Francesca ; Ardoino, Ilaria ; Boracchi, Patrizia ; Cutolo, Maurizio ; Airò, Paolo ; Ananieva, Lidia P. ; Ancuta, Codrina ; Andrade, Luis Eduardo ; Becvar, Radim ; Benenati, Alessia ; Caramaschi, Paola ; Carreira, Patricia E. ; Cuomo, Giovanna ; Damjanov, Nemanja ; Distler, Oliver ; Foti, Rosario ; Guiducci, Serena ; Hachulla, Eric ; Highton, John ; Kayser, Cristiane ; Lubatti, Chiara ; Cerinic, Marco Matucci ; Meier, Florian ; Meroni, Pier Luigi ; Mihai, Carmen Marina ; Morgiel, Ewa ; Müller-Ladner, Ulf ; Loyo, Esthela ; Ortiz, Vera ; Riccieri, Valeria ; Scheja, Agneta ; Skacelova, Simona ; Smith, Vanessa ; Stamenkovic, Bojana ; Stebbings, Simon ; Stoica, Viktor ; Sulli, Alberto ; Szechinski, Jacek ; Tyndall, Alan ; Valentini, Gabriele ; Walker, Ulrich ; Zeni, Silvana ; Zlatanovic, Maja. / Nailfold capillaroscopy in systemic sclerosis : Data from the EULAR scleroderma trials and research (EUSTAR) database. In: Microvascular Research. 2013 ; Vol. 89. pp. 122-128.
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abstract = "Objective: The aims of this study were to obtain cross-sectional data on capillaroscopy in an international multi-center cohort of Systemic Sclerosis (SSc) and to investigate the frequency of the capillaroscopic patterns and their disease-phenotype associations. Methods: Data collected between June 2004 and October 2011 in the EULAR Scleroderma Trials and Research (EUSTAR) registry were examined. Patients' profiles based on clinical and laboratory data were obtained by cluster analysis and the association between profiles and capillaroscopy was investigated by multinomial logistic regression. Results: 62 of the 110 EUSTAR centers entered data on capillaroscopy in the EUSTAR database. 376 of the 2754 patients (13.65{\%}) were classified as scleroderma pattern absent, but non-specific capillary abnormalities were noted in 55.48{\%} of the cases. Four major patients' profiles were identified characterized by a progressive severity for skin involvement, as well as an increased number of systemic manifestations. The early and active scleroderma patterns were generally observed in patients with mild/moderate skin involvement and a low number of disease manifestations, while the late scleroderma pattern was found more frequently in the more severe forms of the disease. Conclusion: These data indicate the importance of capillaroscopy in SSc management and that capillaroscopic patterns are directly related to the extent of organ involvement.",
author = "Francesca Ingegnoli and Ilaria Ardoino and Patrizia Boracchi and Maurizio Cutolo and Paolo Air{\`o} and Ananieva, {Lidia P.} and Codrina Ancuta and Andrade, {Luis Eduardo} and Radim Becvar and Alessia Benenati and Paola Caramaschi and Carreira, {Patricia E.} and Giovanna Cuomo and Nemanja Damjanov and Oliver Distler and Rosario Foti and Serena Guiducci and Eric Hachulla and John Highton and Cristiane Kayser and Chiara Lubatti and Cerinic, {Marco Matucci} and Florian Meier and Meroni, {Pier Luigi} and Mihai, {Carmen Marina} and Ewa Morgiel and Ulf M{\"u}ller-Ladner and Esthela Loyo and Vera Ortiz and Valeria Riccieri and Agneta Scheja and Simona Skacelova and Vanessa Smith and Bojana Stamenkovic and Simon Stebbings and Viktor Stoica and Alberto Sulli and Jacek Szechinski and Alan Tyndall and Gabriele Valentini and Ulrich Walker and Silvana Zeni and Maja Zlatanovic",
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T2 - Data from the EULAR scleroderma trials and research (EUSTAR) database

AU - Ingegnoli, Francesca

AU - Ardoino, Ilaria

AU - Boracchi, Patrizia

AU - Cutolo, Maurizio

AU - Airò, Paolo

AU - Ananieva, Lidia P.

AU - Ancuta, Codrina

AU - Andrade, Luis Eduardo

AU - Becvar, Radim

AU - Benenati, Alessia

AU - Caramaschi, Paola

AU - Carreira, Patricia E.

AU - Cuomo, Giovanna

AU - Damjanov, Nemanja

AU - Distler, Oliver

AU - Foti, Rosario

AU - Guiducci, Serena

AU - Hachulla, Eric

AU - Highton, John

AU - Kayser, Cristiane

AU - Lubatti, Chiara

AU - Cerinic, Marco Matucci

AU - Meier, Florian

AU - Meroni, Pier Luigi

AU - Mihai, Carmen Marina

AU - Morgiel, Ewa

AU - Müller-Ladner, Ulf

AU - Loyo, Esthela

AU - Ortiz, Vera

AU - Riccieri, Valeria

AU - Scheja, Agneta

AU - Skacelova, Simona

AU - Smith, Vanessa

AU - Stamenkovic, Bojana

AU - Stebbings, Simon

AU - Stoica, Viktor

AU - Sulli, Alberto

AU - Szechinski, Jacek

AU - Tyndall, Alan

AU - Valentini, Gabriele

AU - Walker, Ulrich

AU - Zeni, Silvana

AU - Zlatanovic, Maja

PY - 2013/9

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