Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity

Laura De Marinis, Antonio Mancini, Giuseppe Folli, Colomba D’Amico, Salvatore M. Corsello, Rosa Sciuto, Anna Tofani, Paola Sambo, Antonino Barbarino

Research output: Contribution to journalArticle

Abstract

The effects of opiate receptor antagonist naloxone on growth hormone (GH) release after growth hormone-releasing hormone (GHRH) administration were investigated, before or after feeding, at 13.00 h, in 20 obese women and in 10 normal women. When GHRH was administered to obese women before a meal at lunch time, the mean peak plasma GH levels were very low. while plasma GH responses significantly increased after feeding. Naloxone, infused at a rate of 1.6 mg/h starting I h before GHRH administration (50 jig i.v. as a bolus), was capable of inhibiting GH release induced by administration of GHRH after feeding. On the contrary, naloxone did not induce significant variations on the fasting GHRH-induced GH release, in normal women, naloxone did not significantly modify the GH response to GHRH, both before and after lunch. The inhibitory effect of naloxone indicates that in obese women there is an increased opioid activity, which could represent an abnormal response of the gastrointestinal tract to food ingestion.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalNeuroendocrinology
Volume50
Issue number5
DOIs
Publication statusPublished - 1989

Keywords

  • GHRH
  • Naloxone
  • Obesity
  • Plasma GH

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

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  • Cite this

    De Marinis, L., Mancini, A., Folli, G., D’Amico, C., Corsello, S. M., Sciuto, R., Tofani, A., Sambo, P., & Barbarino, A. (1989). Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity. Neuroendocrinology, 50(5), 529-532. https://doi.org/10.1159/000125276