Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity

Laura De Marinis, Antonio Mancini, Giuseppe Folli, Colomba D’Amico, Salvatore M. Corsello, Rosa Sciuto, Anna Tofani, Paola Sambo, Antonino Barbarino

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effects of opiate receptor antagonist naloxone on growth hormone (GH) release after growth hormone-releasing hormone (GHRH) administration were investigated, before or after feeding, at 13.00 h, in 20 obese women and in 10 normal women. When GHRH was administered to obese women before a meal at lunch time, the mean peak plasma GH levels were very low. while plasma GH responses significantly increased after feeding. Naloxone, infused at a rate of 1.6 mg/h starting I h before GHRH administration (50 jig i.v. as a bolus), was capable of inhibiting GH release induced by administration of GHRH after feeding. On the contrary, naloxone did not induce significant variations on the fasting GHRH-induced GH release, in normal women, naloxone did not significantly modify the GH response to GHRH, both before and after lunch. The inhibitory effect of naloxone indicates that in obese women there is an increased opioid activity, which could represent an abnormal response of the gastrointestinal tract to food ingestion.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalNeuroendocrinology
Volume50
Issue number5
DOIs
Publication statusPublished - 1989

Fingerprint

Growth Hormone-Releasing Hormone
Naloxone
Growth Hormone
Obesity
Lunch
Opioid Receptors
Opioid Analgesics
Meals
Gastrointestinal Tract
Inhibition (Psychology)
Fasting
Eating
Food

Keywords

  • GHRH
  • Naloxone
  • Obesity
  • Plasma GH

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

De Marinis, L., Mancini, A., Folli, G., D’Amico, C., Corsello, S. M., Sciuto, R., ... Barbarino, A. (1989). Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity. Neuroendocrinology, 50(5), 529-532. https://doi.org/10.1159/000125276

Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity. / De Marinis, Laura; Mancini, Antonio; Folli, Giuseppe; D’Amico, Colomba; Corsello, Salvatore M.; Sciuto, Rosa; Tofani, Anna; Sambo, Paola; Barbarino, Antonino.

In: Neuroendocrinology, Vol. 50, No. 5, 1989, p. 529-532.

Research output: Contribution to journalArticle

De Marinis, L, Mancini, A, Folli, G, D’Amico, C, Corsello, SM, Sciuto, R, Tofani, A, Sambo, P & Barbarino, A 1989, 'Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity', Neuroendocrinology, vol. 50, no. 5, pp. 529-532. https://doi.org/10.1159/000125276
De Marinis, Laura ; Mancini, Antonio ; Folli, Giuseppe ; D’Amico, Colomba ; Corsello, Salvatore M. ; Sciuto, Rosa ; Tofani, Anna ; Sambo, Paola ; Barbarino, Antonino. / Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity. In: Neuroendocrinology. 1989 ; Vol. 50, No. 5. pp. 529-532.
@article{8e68cfbd2fde425e8afefb0046d41b9d,
title = "Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity",
abstract = "The effects of opiate receptor antagonist naloxone on growth hormone (GH) release after growth hormone-releasing hormone (GHRH) administration were investigated, before or after feeding, at 13.00 h, in 20 obese women and in 10 normal women. When GHRH was administered to obese women before a meal at lunch time, the mean peak plasma GH levels were very low. while plasma GH responses significantly increased after feeding. Naloxone, infused at a rate of 1.6 mg/h starting I h before GHRH administration (50 jig i.v. as a bolus), was capable of inhibiting GH release induced by administration of GHRH after feeding. On the contrary, naloxone did not induce significant variations on the fasting GHRH-induced GH release, in normal women, naloxone did not significantly modify the GH response to GHRH, both before and after lunch. The inhibitory effect of naloxone indicates that in obese women there is an increased opioid activity, which could represent an abnormal response of the gastrointestinal tract to food ingestion.",
keywords = "GHRH, Naloxone, Obesity, Plasma GH",
author = "{De Marinis}, Laura and Antonio Mancini and Giuseppe Folli and Colomba D’Amico and Corsello, {Salvatore M.} and Rosa Sciuto and Anna Tofani and Paola Sambo and Antonino Barbarino",
year = "1989",
doi = "10.1159/000125276",
language = "English",
volume = "50",
pages = "529--532",
journal = "Neuroendocrinology",
issn = "0028-3835",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity

AU - De Marinis, Laura

AU - Mancini, Antonio

AU - Folli, Giuseppe

AU - D’Amico, Colomba

AU - Corsello, Salvatore M.

AU - Sciuto, Rosa

AU - Tofani, Anna

AU - Sambo, Paola

AU - Barbarino, Antonino

PY - 1989

Y1 - 1989

N2 - The effects of opiate receptor antagonist naloxone on growth hormone (GH) release after growth hormone-releasing hormone (GHRH) administration were investigated, before or after feeding, at 13.00 h, in 20 obese women and in 10 normal women. When GHRH was administered to obese women before a meal at lunch time, the mean peak plasma GH levels were very low. while plasma GH responses significantly increased after feeding. Naloxone, infused at a rate of 1.6 mg/h starting I h before GHRH administration (50 jig i.v. as a bolus), was capable of inhibiting GH release induced by administration of GHRH after feeding. On the contrary, naloxone did not induce significant variations on the fasting GHRH-induced GH release, in normal women, naloxone did not significantly modify the GH response to GHRH, both before and after lunch. The inhibitory effect of naloxone indicates that in obese women there is an increased opioid activity, which could represent an abnormal response of the gastrointestinal tract to food ingestion.

AB - The effects of opiate receptor antagonist naloxone on growth hormone (GH) release after growth hormone-releasing hormone (GHRH) administration were investigated, before or after feeding, at 13.00 h, in 20 obese women and in 10 normal women. When GHRH was administered to obese women before a meal at lunch time, the mean peak plasma GH levels were very low. while plasma GH responses significantly increased after feeding. Naloxone, infused at a rate of 1.6 mg/h starting I h before GHRH administration (50 jig i.v. as a bolus), was capable of inhibiting GH release induced by administration of GHRH after feeding. On the contrary, naloxone did not induce significant variations on the fasting GHRH-induced GH release, in normal women, naloxone did not significantly modify the GH response to GHRH, both before and after lunch. The inhibitory effect of naloxone indicates that in obese women there is an increased opioid activity, which could represent an abnormal response of the gastrointestinal tract to food ingestion.

KW - GHRH

KW - Naloxone

KW - Obesity

KW - Plasma GH

UR - http://www.scopus.com/inward/record.url?scp=0024419548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024419548&partnerID=8YFLogxK

U2 - 10.1159/000125276

DO - 10.1159/000125276

M3 - Article

C2 - 2558324

AN - SCOPUS:0024419548

VL - 50

SP - 529

EP - 532

JO - Neuroendocrinology

JF - Neuroendocrinology

SN - 0028-3835

IS - 5

ER -