Naloxone-reversible effects of ethanol on passive avoidance behavior in mice

Claudio Castellano, Flaminia Pavone

Research output: Contribution to journalArticlepeer-review

Abstract

Performance impairments were evident, in CD1 mice tested in a passive avoidance apparatus, following posttrial intraperitoneal administration of ethanol (1.0 and 2.0 g/kg) or morphine (0.5 and 1.0 mg/kg), or following posttrial immobilization stress (30 and 60 min). Lower doses of ethanol (0.5 g/kg) or morphine (0.25 mg/kg), or a shorter immobilization time (15 min) were ineffective. Ethanol, at an ineffective dose (0.50 g/kg) enhanced both the effects of morphine and those of immobilization stress. The effects observed were antagonized by a per se ineffective dose of naloxone (1.0 mg/kg). The possibility that opiates may have a critical but modulatory effect on the actions of ethanol and/or immobilization is discussed.

Original languageEnglish
Pages (from-to)291-295
Number of pages5
JournalPhysiological Psychology
Volume11
Issue number4
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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