Naltrexone, naltrindole, and CTOP block cocaine-induced sensitization to seizures and death

D. Braida, E. Paladini, E. Gori, M. Sala

Research output: Contribution to journalArticlepeer-review

Abstract

ICV injection for 9 days of either nallexone (NTX) (5, 10, 20, 40 μg/rat) or a selective μ peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 μg/rat) or δ (naltrindole) (NLT) (5, 10, 20 μg/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, IP) administered 10 min after. NTX (5 and 40 μg/rat). NLT (10 and 20 μg/rat), and the peptide CTOP (0.25 0.5 μg/rat) attenuated seizure parameters (percent of animals showing seizures, mean score and latency) in a day- related manner. The DD(SD) (days to reach 50% of death) value for COC was 2.69, whereas it was 9.67 and 7.47 for NTX 5 and 40 μg/cal. 8.59 for NLT (10 μg/rat), and 6.11, 5.95, and 4.30 for CTOP (0.25, 0.5 and 1 μg/rat respectively). These findings suggest a concurrent involvement of μ and δ- opioid receptor subtype in COC induced sensitization to toxic effects.

Original languageEnglish
Pages (from-to)1189-1195
Number of pages7
JournalPeptides
Volume18
Issue number8
DOIs
Publication statusPublished - 1997

Keywords

  • μ and δ Opioid receptor
  • Central administration
  • Lethality
  • Pharmacological kindling
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Naltrexone, naltrindole, and CTOP block cocaine-induced sensitization to seizures and death'. Together they form a unique fingerprint.

Cite this