Naltrexone-reversible effects of flunitrazepam on locomotor activity and passive avoidance behaviour in mice

Claudio Castellano, Umberto Filibeck, Flaminia Pavone

Research output: Contribution to journalArticlepeer-review

Abstract

Some behavioural effects of flunitrazepam were investigated in two sets of experiment in C57BL/6 mice. In the first set, funitrazepam administration (0.025 or 0.05 mg/kg) enhanced the locomotor activity of mice. In the second set, memory impairments were observed following posttraining (immediately or 30 min, but not 60 min) treatment with the drug (0.05 mg/kg). All effects were antagonized by a per ineffective dose of naltrexone (0.5 mg/kg for the activity, 0.1 mg/kg for the memory experiments), suggesting the involvement of opioid receptors. The results are discussed on the basis of recent evidence suggesting a link between benzodiazepine and opiate mechanisms of action.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalEuropean Journal of Pharmacology
Volume104
Issue number1-2
DOIs
Publication statusPublished - Sep 3 1984

Keywords

  • Endogenous opioids
  • Flunitrazepam
  • Mice
  • Naltrexone

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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