Nanocrystalline hydroxyapatite-polyaspartate composites

A. Bigi, E. Boanini, M. Gazzano, K. Rubini, P. Torricelli

Research output: Contribution to journalArticlepeer-review


The direct synthesis of hydroxyapatite-poly-L-aspartic acid (HA-PASP) nanocrystals has been carried out in presence of increasing amounts of PASP in solution up to 56 mmol/l. WAXS, TEM, TGA, IR and chemical analyses were used to characterize the structure, morphology and composition of the products. PASP is quantitatively incorporated into HA crystals, provoking a reduction of the coherent length of the crystalline domains. Furthermore, composite crystals display a greater length/width ratio with respect to the control HA crystals, and show a remarkable trend towards aggregation. The broadening of the X-ray diffraction reflections indicate a reduction of the coherent length along the long dimension 002 and the cross section 310 of the apatite crystals. The comparison between the morphological and structural data allows to suggest a specific interaction between PASP and HA structure.

Original languageEnglish
Pages (from-to)573-579
Number of pages7
JournalBio-Medical Materials and Engineering
Issue number4
Publication statusPublished - 2004


  • Crystal size
  • Hydroxyapatite
  • Nanocrystals
  • Poly-L-aspartic acid
  • X-ray diffraction

ASJC Scopus subject areas

  • Biophysics


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