Nanoparticle-mediated drug delivery to high-grade gliomas

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

High grade gliomas (HGGs) are fatal brain tumors due to their infiltration capacity and the presence of resistant cell populations. Further, the brain is naturally protected from many exogenous molecules by the brain blood barrier (BBB), which limits or cancels passage of cytotoxic drugs to the tumor sites. In order to cope with the latter problem, nanoparticle (NP)-based carriers are intensively investigated, due to multiple possibilities to drive them across the BBB to the tumor sites and drop cytotoxic molecules there. The current status of research on NP for drug delivery to HGGs has been analyzed. The results indicate gold, lipids and proteins as three main materials featuring NP formulations for HGG treatment. Albeit specific drug targeting to HGG cells may have not been so far significantly improved, NP may help drugs crossing the BBB and enter the brain thus potentially fixing at least one part of the problem.

Original languageEnglish
Pages (from-to)1083-1093
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume12
Issue number4
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Drug delivery
Glioma
Nanoparticles
Blood-Brain Barrier
Tumors
Brain
Pharmaceutical Preparations
Molecules
Drug Delivery Systems
Infiltration
Brain Neoplasms
Gold
Lipids
Neoplasms
Cells
Proteins
Research
Population
Therapeutics

Keywords

  • Brain blood barrier
  • Drug delivery
  • Glioma
  • Gold
  • Nanoparticle
  • Tumor targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

Cite this

Nanoparticle-mediated drug delivery to high-grade gliomas. / Frosina, Guido.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 12, No. 4, 01.05.2016, p. 1083-1093.

Research output: Contribution to journalArticle

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