Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery

Alessandra Luchini, Caterina Longo, Virginia Espina, Emanuel F. Petricoin, Lance A. Liotta

Research output: Contribution to journalArticle

Abstract

The incorporation of affinity baits into N-isopropylacrylamide-hydrogel- based nanoparticles offers a novel technology that addresses the major analytical challenges of disease biomarker discovery. In solution in complex biologic fluids (e.g. blood or urine), core-shell bait-containing nanoparticles can perform three functions in one step: (a) sieve molecules according to size, (b) sequestrate and concentrate target analytes, and (c) protect analytes from degradation.

Original languageEnglish
Pages (from-to)5071-5077
Number of pages7
JournalJournal of Materials Chemistry
Volume19
Issue number29
DOIs
Publication statusPublished - Aug 7 2009

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ASJC Scopus subject areas

  • Materials Chemistry
  • Chemistry(all)

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