Nanoparticles for therapy of Alzheimer Disease

M. Masserini, M. Salmona, M. Gregori, G. Forloni, F. Re

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

NAD project (large cooperative; 19 partners, funded by the E.C., FP72007-2013, G.A. n° 212043) is aiming to the therapy and diagnosis, even combined, of Alzheimer Disease, by creating different multiple-functionalized nanoparticles, able to bind, detect and remove p-amyloid peptide (Aβ) from the brain and from the blood. The results obtained so far show the ability of liposomes functionalized to bind Abeta, to cross the blood-brain barrier either in vitro and in vivo and to reduce the Aβ burden from the brain of transgenic animal models of the disease, thus opening new vistas for the possible therapy of Alzheimer Disease in humans.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages339-342
Number of pages4
Volume3
Publication statusPublished - 2013
EventNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States
Duration: May 12 2013May 16 2013

Other

OtherNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
CountryUnited States
CityWashington, DC
Period5/12/135/16/13

Keywords

  • Abeta
  • Alzheimer
  • Liposomes

ASJC Scopus subject areas

  • Biotechnology

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  • Cite this

    Masserini, M., Salmona, M., Gregori, M., Forloni, G., & Re, F. (2013). Nanoparticles for therapy of Alzheimer Disease. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (Vol. 3, pp. 339-342)