Nanoparticles in detection and treatment of lymph node metastases: an update from the point of view of administration routes

Antonella Obinu, Elisabetta Gavini, Giovanna Rassu, Marcello Maestri, Maria Cristina Bonferoni, Paolo Giunchedi

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Lymphatic vessels are the preferential route of most solid tumors to spread their metastases in the body. Therefore, the individuation and elimination of cancer cells within the lymphatic system (LS) is an important goal. Nanoparticles (NPs), thanks to their small size, represent suitable carriers for imaging and for chemotherapeutic transport to the LS. An update of different nanoparticle delivery systems developed for the detection and treatment of lymphatic metastases has been made, classified from the point of view of the administration routes used. Areas covered: The role of the LS in tumor progression and importance of treatment and imaging strategies of lymphatic metastases; classification, with regard the administration route, of nanoparticle delivery system used to target lymph node (LN) metastases. Expert opinion: The NPs are a promising approach for the treatment and detection of lymphatic metastases. However, further studies are necessary to evaluate their efficacy in human clinical application.

Original languageEnglish
Pages (from-to)1117-1126
Number of pages10
JournalExpert Opinion on Drug Delivery
Volume15
Issue number11
DOIs
Publication statusPublished - Nov 2 2018
Externally publishedYes

Keywords

  • administration routes
  • cancer imaging
  • Lymph node metastases
  • nanoparticles
  • tumor treatment

ASJC Scopus subject areas

  • Pharmaceutical Science

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