Nanoparticles to improve the efficacy of peptide-based cancer vaccines

Anna Lucia Tornesello, Maria Tagliamonte, Maria Lina Tornesello, Franco M. Buonaguro, Luigi Buonaguro

Research output: Contribution to journalReview article

Abstract

Nanoparticles represent a potent antigen presentation and delivery system to elicit an optimal immune response by effector cells targeting tumor-associated antigens expressed by cancer cells. Many types of nanoparticles have been developed, such as polymeric complexes, liposomes, micelles and protein-based structures such as virus like particles. All of them show promising results for immunotherapy approaches. In particular, the immunogenicity of peptide-based cancer vaccines can be significantly potentiated by nanoparticles. Indeed, nanoparticles are able to enhance the targeting of antigen-presenting cells (APCs) and trigger cytokine production for optimal T cell response. The present review summarizes the categories of nanoparticles and peptide cancer vaccines which are currently under pre-clinical evaluation.

Original languageEnglish
Article number1049
JournalCancers
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Cancer vaccines
  • CPPs
  • Nanoparticles
  • Peptide-based vaccine
  • Tumor vaccines
  • VLPs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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