Nanosensors for early cancer detection and for therapeutic drug monitoring

Elisa Salvati, Francesco Stellacci, Silke Krol

Research output: Contribution to journalArticle

Abstract

The use of nanotechnology for drug delivery in cancer therapy has raised high expectations. Additionally, the use of nanomaterials in sensors to extract and detect tumor specific biomarkers, circulating tumor cells, or extracellular vesicles shed by the tumor holds the promise to detect cancer much earlier and hence improve long-term survival of the patients. Moreover, the monitoring of the anticancer drug concentration, which has a narrow therapeutic window, will allow for a personalized dosing of the drug and will lead to improved therapeutic outcome and life quality of the patient. This review will provide an overview on the use of nanosensors for the early diagnosis of cancer and for the therapeutic drug monitoring, giving some examples. We envision nanosensors to make significant improvements in the cancer management as easy-to-use point-of-care devices for a broad population of users.

Original languageEnglish
Pages (from-to)3495-3512
Number of pages18
JournalNanomedicine
Volume10
Issue number23
DOIs
Publication statusPublished - Dec 1 2015

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Keywords

  • biomarkers
  • circulating tumor cells
  • exosomes
  • nanoparticles
  • nanosensors
  • therapeutic drug monitoring

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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