TY - JOUR
T1 - Nanotechnology advances in brain tumors
T2 - The state of the art
AU - Invernici, Gloria
AU - Cristini, Silvia
AU - Alessandri, Giulio
AU - Navone, Stefania E.
AU - Canzi, Laura
AU - Tavian, Daniela
AU - Redaelli, Chiara
AU - Acerbi, Francesco
AU - Parati, Eugenio A.
PY - 2011
Y1 - 2011
N2 - Primary malignant central nervous system (CNS) tumors only represent about 2% of all cancers. However, they are very often associated with high morbidity and mortality. Despite current standard-of-care therapy, such as surgery, irradiation, and chemotherapy, neither cure nor any toxic therapy against malignant CNS tumors has been developed so far. Nanotechnology may alter this situation. It offers a new promise for cancer diagnosis and treatment. This emerging technology, by developing and manufacturing materials using atomic and molecular elements, can provide a platform for the combination of diagnostics, therapeutics and delivery to the tumor, with subsequent monitoring of the response. This review focuses on recent developments in cancer nanotechnology with particular attention to nanoparticle systems, important tools for the improvement of drug delivery in brain tumor. The latest advances in both the research sector and in recent patents for cancer imaging and therapy are discussed.
AB - Primary malignant central nervous system (CNS) tumors only represent about 2% of all cancers. However, they are very often associated with high morbidity and mortality. Despite current standard-of-care therapy, such as surgery, irradiation, and chemotherapy, neither cure nor any toxic therapy against malignant CNS tumors has been developed so far. Nanotechnology may alter this situation. It offers a new promise for cancer diagnosis and treatment. This emerging technology, by developing and manufacturing materials using atomic and molecular elements, can provide a platform for the combination of diagnostics, therapeutics and delivery to the tumor, with subsequent monitoring of the response. This review focuses on recent developments in cancer nanotechnology with particular attention to nanoparticle systems, important tools for the improvement of drug delivery in brain tumor. The latest advances in both the research sector and in recent patents for cancer imaging and therapy are discussed.
KW - Cancer treatment
KW - Drug delivery
KW - Gene therapy
KW - Nanoparticle
KW - Nanotechnology
KW - Patent
UR - http://www.scopus.com/inward/record.url?scp=78650959917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650959917&partnerID=8YFLogxK
U2 - 10.2174/157489211793979990
DO - 10.2174/157489211793979990
M3 - Article
C2 - 21110824
AN - SCOPUS:78650959917
VL - 6
SP - 58
EP - 69
JO - Recent Patents on Anti-Cancer Drug Discovery
JF - Recent Patents on Anti-Cancer Drug Discovery
SN - 1574-8928
IS - 1
ER -