Nanotechnology in the Treatment of Inflammatory Bowel Disease

Fanny Giron, Anna Pastó, Ennio Tasciotti, Bincy P Abraham

Research output: Contribution to journalArticle

Abstract

Due to the lack of cure for inflammatory bowel disease (IBD) and failure of current medical therapies in many patients with IBD, a need exists in finding novel ways to treat inflammation with a high benefit and the lowest risk possible. With current medical therapies, adverse events or risks of cancer/lymphoma and infections prevent patients-and sometimes providers-in using effective therapies for treatment. Some patients develop systemic side effects that preclude them from continuing a therapy that may have been efficacious, or in other cases, current medical therapies are not adequate to control disease. Nanotechnology is an emerging field where particles, in the size of nanometers, can be used to deliver medications directly to the area of inflammation thus avoiding drug-associated systemic side effects. When using nanoparticles (NPs), only a small amount of the drug is needed, and it can be delivered directly to the inflamed site without exposure to the rest of the body. Here we review conventional and unconventional therapies applied in the treatment of IBD underlying how the introduction of NPs has improved their safety and efficacy.

Original languageEnglish
Pages (from-to)1871-1880
Number of pages10
JournalInflammatory Bowel Diseases
Volume25
Issue number12
DOIs
Publication statusPublished - Nov 14 2019

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Giron, F., Pastó, A., Tasciotti, E., & Abraham, B. P. (2019). Nanotechnology in the Treatment of Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(12), 1871-1880. https://doi.org/10.1093/ibd/izz205