Nanotoxicology and safety evaluation of nanomedicines

Luigi Manzo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the last years, advanced toxicological methods and new research approaches have been proposed to improve and refine safety assessment of nanomaterials. High-throughput technologies, molecular markers, molecular imaging, and other tools originated from advanced research in nanotoxicology offer an exciting opportunity to improve the efficacy and predictivity of toxicity testing for candidate nanomedicines. Testing based on these novel research technologies can be conducted at low, clinically relevant doses focusing on what really represents an "adverse" response or a reliable indicator of adverse health outcome. When applied to candidate nanomedicines, this modern vision of toxicity testing can valuably contribute to address safety concerns, reduce regulatory uncertainties, expedite drug development, and sustain translation of nanotechnology enabled products to the clinic.

Original languageEnglish
Title of host publication14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages18-21
Number of pages4
ISBN (Print)9781479956227
DOIs
Publication statusPublished - Nov 26 2014
Event2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014 - Toronto, Canada
Duration: Aug 18 2014Aug 21 2014

Other

Other2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014
CountryCanada
CityToronto
Period8/18/148/21/14

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Modelling and Simulation
  • Instrumentation

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