Narcolepsy and pregnancy: A retrospective European evaluation of 249 pregnancies

Eszter Maurovich-Horvat, David Kemlink, Birgit Högl, Birgit Frauscher, Laura Ehrmann, Peter Geisler, Katharina Ettenhuber, Geert Mayer, Rosa Peraita-Adrados, Elena Calvo, Gert Jan Lammers, Astrid Van der Heide, Luigi Ferini-Strambi, Giuseppe Plazzi, Francesca Poli, Yves Dauvilliers, Poul Jennum, Helle Leonthin, Johannes Mathis, Aleksandra WierzbickaFrancisco J. Puertas, Pierre A. Beitinger, Isabelle Arnulf, Renata L. Riha, Maria Tormášiová, Jana Slonková, Sona Nevšímalová, Karel Šonka

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P <0.001) and had a higher body mass index (BMI) prior to pregnancy (P <0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P <0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P <0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult.

Original languageEnglish
Pages (from-to)496-512
Number of pages17
JournalJournal of Sleep Research
Volume22
Issue number5
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Narcolepsy
Cataplexy
Pregnancy
Cesarean Section
Body Mass Index
Infant Care
Glucose
Birth Weight
Gestational Age
Obstetrics
Weight Gain
Anemia
Reference Values
Cohort Studies

Keywords

  • Cataplexy
  • Delivery
  • Metabolism
  • Newborn
  • Pregnancy
  • Puerperium

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Maurovich-Horvat, E., Kemlink, D., Högl, B., Frauscher, B., Ehrmann, L., Geisler, P., ... Šonka, K. (2013). Narcolepsy and pregnancy: A retrospective European evaluation of 249 pregnancies. Journal of Sleep Research, 22(5), 496-512. https://doi.org/10.1111/jsr.12047

Narcolepsy and pregnancy : A retrospective European evaluation of 249 pregnancies. / Maurovich-Horvat, Eszter; Kemlink, David; Högl, Birgit; Frauscher, Birgit; Ehrmann, Laura; Geisler, Peter; Ettenhuber, Katharina; Mayer, Geert; Peraita-Adrados, Rosa; Calvo, Elena; Lammers, Gert Jan; Van der Heide, Astrid; Ferini-Strambi, Luigi; Plazzi, Giuseppe; Poli, Francesca; Dauvilliers, Yves; Jennum, Poul; Leonthin, Helle; Mathis, Johannes; Wierzbicka, Aleksandra; Puertas, Francisco J.; Beitinger, Pierre A.; Arnulf, Isabelle; Riha, Renata L.; Tormášiová, Maria; Slonková, Jana; Nevšímalová, Sona; Šonka, Karel.

In: Journal of Sleep Research, Vol. 22, No. 5, 10.2013, p. 496-512.

Research output: Contribution to journalArticle

Maurovich-Horvat, E, Kemlink, D, Högl, B, Frauscher, B, Ehrmann, L, Geisler, P, Ettenhuber, K, Mayer, G, Peraita-Adrados, R, Calvo, E, Lammers, GJ, Van der Heide, A, Ferini-Strambi, L, Plazzi, G, Poli, F, Dauvilliers, Y, Jennum, P, Leonthin, H, Mathis, J, Wierzbicka, A, Puertas, FJ, Beitinger, PA, Arnulf, I, Riha, RL, Tormášiová, M, Slonková, J, Nevšímalová, S & Šonka, K 2013, 'Narcolepsy and pregnancy: A retrospective European evaluation of 249 pregnancies', Journal of Sleep Research, vol. 22, no. 5, pp. 496-512. https://doi.org/10.1111/jsr.12047
Maurovich-Horvat E, Kemlink D, Högl B, Frauscher B, Ehrmann L, Geisler P et al. Narcolepsy and pregnancy: A retrospective European evaluation of 249 pregnancies. Journal of Sleep Research. 2013 Oct;22(5):496-512. https://doi.org/10.1111/jsr.12047
Maurovich-Horvat, Eszter ; Kemlink, David ; Högl, Birgit ; Frauscher, Birgit ; Ehrmann, Laura ; Geisler, Peter ; Ettenhuber, Katharina ; Mayer, Geert ; Peraita-Adrados, Rosa ; Calvo, Elena ; Lammers, Gert Jan ; Van der Heide, Astrid ; Ferini-Strambi, Luigi ; Plazzi, Giuseppe ; Poli, Francesca ; Dauvilliers, Yves ; Jennum, Poul ; Leonthin, Helle ; Mathis, Johannes ; Wierzbicka, Aleksandra ; Puertas, Francisco J. ; Beitinger, Pierre A. ; Arnulf, Isabelle ; Riha, Renata L. ; Tormášiová, Maria ; Slonková, Jana ; Nevšímalová, Sona ; Šonka, Karel. / Narcolepsy and pregnancy : A retrospective European evaluation of 249 pregnancies. In: Journal of Sleep Research. 2013 ; Vol. 22, No. 5. pp. 496-512.
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