TY - JOUR
T1 - Narcolepsy with cataplexy associated with nocturnal compulsive behaviors
T2 - A case-control study
AU - Palaia, Vincenzo
AU - Poli, Francesca
AU - Pizza, Fabio
AU - Antelmi, Elena
AU - Franceschini, Christian
AU - Moghadam, Keivan Kaveh
AU - Provini, Frederica
AU - Pagotto, Uberto
AU - Montagna, Pasquale
AU - Schenck, Carlos H.
AU - Mignot, Emmanuel
AU - Plazzi, Giuseppe
PY - 2011/10/1
Y1 - 2011/10/1
N2 - Study Objectives: To assess the prevalence of sleep related-eating disorder (SRED ) and nocturnal smoking (NS) in patients with narcolepsy with cataplexy (NC). Design: Case-control study. Setting: University hospital. Patients or Participants: 65 consecutive adult NC patients (33 men; mean age 43.9 ± 19.2 years) and 65 age-, sex-, and geographical origin-matched controls. Interventions: Validated questionnaires were used to investigate SRED , NS, restless legs syndrome (RLS ), and psychopathological traits (using Eating Disorder Inventory-2 [EDI-2]; Maudsley Obsessive-Compulsive Inventory [MOCI]; and Beck Depression Inventory [BDI]). Measurements and Results: NC patients showed a higher prevalence of SRED (32% vs 3%, P = 0.00001), NS (21% vs 0%, P = 0.00006), and RLS (18% vs 5%, P = 0.013) than controls. Moreover, NC patients presented more frequently with an eating-related pathological profile on the EDI-2 (80% vs 46%, P = 0.00006) and had a higher prevalence of depressed mood on the BDI (41% vs 18%, P = 0.004). In comparison to patients without SRED, NC patients with SRED were more frequently women (71% vs 39%, P = 0.013), had higher "bulimic" (29% vs 2%, P = 0.004) and "social insecurity" (48% vs 18%, P = 0.013) traits on the EDI-2, had higher obsessive-compulsiveness on the MOCI (29% vs 4%, P = 0.009), and were more depressed on the BDI (67% vs 29%, P = 0.005). NC patients with NS showed more frequent pathological profiles on the EDI-2 (100% vs 75%, P = 0.035), including the "bulimic" (29% vs 6%, P = 0.015), "perfectionism" (43% vs 14%, P = 0.016), and "social insecurity" (50% vs 22, P = 0.035) profiles. Conclusion: Our study shows a strong association of the compulsive nocturnal behaviors SRED and NS with adult NC.
AB - Study Objectives: To assess the prevalence of sleep related-eating disorder (SRED ) and nocturnal smoking (NS) in patients with narcolepsy with cataplexy (NC). Design: Case-control study. Setting: University hospital. Patients or Participants: 65 consecutive adult NC patients (33 men; mean age 43.9 ± 19.2 years) and 65 age-, sex-, and geographical origin-matched controls. Interventions: Validated questionnaires were used to investigate SRED , NS, restless legs syndrome (RLS ), and psychopathological traits (using Eating Disorder Inventory-2 [EDI-2]; Maudsley Obsessive-Compulsive Inventory [MOCI]; and Beck Depression Inventory [BDI]). Measurements and Results: NC patients showed a higher prevalence of SRED (32% vs 3%, P = 0.00001), NS (21% vs 0%, P = 0.00006), and RLS (18% vs 5%, P = 0.013) than controls. Moreover, NC patients presented more frequently with an eating-related pathological profile on the EDI-2 (80% vs 46%, P = 0.00006) and had a higher prevalence of depressed mood on the BDI (41% vs 18%, P = 0.004). In comparison to patients without SRED, NC patients with SRED were more frequently women (71% vs 39%, P = 0.013), had higher "bulimic" (29% vs 2%, P = 0.004) and "social insecurity" (48% vs 18%, P = 0.013) traits on the EDI-2, had higher obsessive-compulsiveness on the MOCI (29% vs 4%, P = 0.009), and were more depressed on the BDI (67% vs 29%, P = 0.005). NC patients with NS showed more frequent pathological profiles on the EDI-2 (100% vs 75%, P = 0.035), including the "bulimic" (29% vs 6%, P = 0.015), "perfectionism" (43% vs 14%, P = 0.016), and "social insecurity" (50% vs 22, P = 0.035) profiles. Conclusion: Our study shows a strong association of the compulsive nocturnal behaviors SRED and NS with adult NC.
KW - Case-control study
KW - Narcolepsy with cataplexy
KW - Nocturnal compulsive behaviors
KW - Nocturnal smoking
KW - Sleep related-eating disorder
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U2 - 10.5665/SLEEP.1280
DO - 10.5665/SLEEP.1280
M3 - Article
C2 - 21966068
AN - SCOPUS:80053514904
VL - 34
SP - 1365
EP - 1371
JO - Sleep
JF - Sleep
SN - 0161-8105
IS - 10
ER -