Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: A case-control study

Vincenzo Palaia, Francesca Poli, Fabio Pizza, Elena Antelmi, Christian Franceschini, Keivan Kaveh Moghadam, Frederica Provini, Uberto Pagotto, Pasquale Montagna, Carlos H. Schenck, Emmanuel Mignot, Giuseppe Plazzi

Research output: Contribution to journalArticle

Abstract

Study Objectives: To assess the prevalence of sleep related-eating disorder (SRED ) and nocturnal smoking (NS) in patients with narcolepsy with cataplexy (NC). Design: Case-control study. Setting: University hospital. Patients or Participants: 65 consecutive adult NC patients (33 men; mean age 43.9 ± 19.2 years) and 65 age-, sex-, and geographical origin-matched controls. Interventions: Validated questionnaires were used to investigate SRED , NS, restless legs syndrome (RLS ), and psychopathological traits (using Eating Disorder Inventory-2 [EDI-2]; Maudsley Obsessive-Compulsive Inventory [MOCI]; and Beck Depression Inventory [BDI]). Measurements and Results: NC patients showed a higher prevalence of SRED (32% vs 3%, P = 0.00001), NS (21% vs 0%, P = 0.00006), and RLS (18% vs 5%, P = 0.013) than controls. Moreover, NC patients presented more frequently with an eating-related pathological profile on the EDI-2 (80% vs 46%, P = 0.00006) and had a higher prevalence of depressed mood on the BDI (41% vs 18%, P = 0.004). In comparison to patients without SRED, NC patients with SRED were more frequently women (71% vs 39%, P = 0.013), had higher "bulimic" (29% vs 2%, P = 0.004) and "social insecurity" (48% vs 18%, P = 0.013) traits on the EDI-2, had higher obsessive-compulsiveness on the MOCI (29% vs 4%, P = 0.009), and were more depressed on the BDI (67% vs 29%, P = 0.005). NC patients with NS showed more frequent pathological profiles on the EDI-2 (100% vs 75%, P = 0.035), including the "bulimic" (29% vs 6%, P = 0.015), "perfectionism" (43% vs 14%, P = 0.016), and "social insecurity" (50% vs 22, P = 0.035) profiles. Conclusion: Our study shows a strong association of the compulsive nocturnal behaviors SRED and NS with adult NC.

Original languageEnglish
Pages (from-to)1365-1371
Number of pages7
JournalSleep
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 1 2011

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Cataplexy
Compulsive Behavior
Narcolepsy
Case-Control Studies
Equipment and Supplies
Sleep
Smoking
Restless Legs Syndrome
Depression
Feeding and Eating Disorders
Eating

Keywords

  • Case-control study
  • Narcolepsy with cataplexy
  • Nocturnal compulsive behaviors
  • Nocturnal smoking
  • Sleep related-eating disorder

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Narcolepsy with cataplexy associated with nocturnal compulsive behaviors : A case-control study. / Palaia, Vincenzo; Poli, Francesca; Pizza, Fabio; Antelmi, Elena; Franceschini, Christian; Moghadam, Keivan Kaveh; Provini, Frederica; Pagotto, Uberto; Montagna, Pasquale; Schenck, Carlos H.; Mignot, Emmanuel; Plazzi, Giuseppe.

In: Sleep, Vol. 34, No. 10, 01.10.2011, p. 1365-1371.

Research output: Contribution to journalArticle

Palaia, V, Poli, F, Pizza, F, Antelmi, E, Franceschini, C, Moghadam, KK, Provini, F, Pagotto, U, Montagna, P, Schenck, CH, Mignot, E & Plazzi, G 2011, 'Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: A case-control study', Sleep, vol. 34, no. 10, pp. 1365-1371. https://doi.org/10.5665/SLEEP.1280
Palaia V, Poli F, Pizza F, Antelmi E, Franceschini C, Moghadam KK et al. Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: A case-control study. Sleep. 2011 Oct 1;34(10):1365-1371. https://doi.org/10.5665/SLEEP.1280
Palaia, Vincenzo ; Poli, Francesca ; Pizza, Fabio ; Antelmi, Elena ; Franceschini, Christian ; Moghadam, Keivan Kaveh ; Provini, Frederica ; Pagotto, Uberto ; Montagna, Pasquale ; Schenck, Carlos H. ; Mignot, Emmanuel ; Plazzi, Giuseppe. / Narcolepsy with cataplexy associated with nocturnal compulsive behaviors : A case-control study. In: Sleep. 2011 ; Vol. 34, No. 10. pp. 1365-1371.
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abstract = "Study Objectives: To assess the prevalence of sleep related-eating disorder (SRED ) and nocturnal smoking (NS) in patients with narcolepsy with cataplexy (NC). Design: Case-control study. Setting: University hospital. Patients or Participants: 65 consecutive adult NC patients (33 men; mean age 43.9 ± 19.2 years) and 65 age-, sex-, and geographical origin-matched controls. Interventions: Validated questionnaires were used to investigate SRED , NS, restless legs syndrome (RLS ), and psychopathological traits (using Eating Disorder Inventory-2 [EDI-2]; Maudsley Obsessive-Compulsive Inventory [MOCI]; and Beck Depression Inventory [BDI]). Measurements and Results: NC patients showed a higher prevalence of SRED (32{\%} vs 3{\%}, P = 0.00001), NS (21{\%} vs 0{\%}, P = 0.00006), and RLS (18{\%} vs 5{\%}, P = 0.013) than controls. Moreover, NC patients presented more frequently with an eating-related pathological profile on the EDI-2 (80{\%} vs 46{\%}, P = 0.00006) and had a higher prevalence of depressed mood on the BDI (41{\%} vs 18{\%}, P = 0.004). In comparison to patients without SRED, NC patients with SRED were more frequently women (71{\%} vs 39{\%}, P = 0.013), had higher {"}bulimic{"} (29{\%} vs 2{\%}, P = 0.004) and {"}social insecurity{"} (48{\%} vs 18{\%}, P = 0.013) traits on the EDI-2, had higher obsessive-compulsiveness on the MOCI (29{\%} vs 4{\%}, P = 0.009), and were more depressed on the BDI (67{\%} vs 29{\%}, P = 0.005). NC patients with NS showed more frequent pathological profiles on the EDI-2 (100{\%} vs 75{\%}, P = 0.035), including the {"}bulimic{"} (29{\%} vs 6{\%}, P = 0.015), {"}perfectionism{"} (43{\%} vs 14{\%}, P = 0.016), and {"}social insecurity{"} (50{\%} vs 22, P = 0.035) profiles. Conclusion: Our study shows a strong association of the compulsive nocturnal behaviors SRED and NS with adult NC.",
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author = "Vincenzo Palaia and Francesca Poli and Fabio Pizza and Elena Antelmi and Christian Franceschini and Moghadam, {Keivan Kaveh} and Frederica Provini and Uberto Pagotto and Pasquale Montagna and Schenck, {Carlos H.} and Emmanuel Mignot and Giuseppe Plazzi",
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AU - Antelmi, Elena

AU - Franceschini, Christian

AU - Moghadam, Keivan Kaveh

AU - Provini, Frederica

AU - Pagotto, Uberto

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N2 - Study Objectives: To assess the prevalence of sleep related-eating disorder (SRED ) and nocturnal smoking (NS) in patients with narcolepsy with cataplexy (NC). Design: Case-control study. Setting: University hospital. Patients or Participants: 65 consecutive adult NC patients (33 men; mean age 43.9 ± 19.2 years) and 65 age-, sex-, and geographical origin-matched controls. Interventions: Validated questionnaires were used to investigate SRED , NS, restless legs syndrome (RLS ), and psychopathological traits (using Eating Disorder Inventory-2 [EDI-2]; Maudsley Obsessive-Compulsive Inventory [MOCI]; and Beck Depression Inventory [BDI]). Measurements and Results: NC patients showed a higher prevalence of SRED (32% vs 3%, P = 0.00001), NS (21% vs 0%, P = 0.00006), and RLS (18% vs 5%, P = 0.013) than controls. Moreover, NC patients presented more frequently with an eating-related pathological profile on the EDI-2 (80% vs 46%, P = 0.00006) and had a higher prevalence of depressed mood on the BDI (41% vs 18%, P = 0.004). In comparison to patients without SRED, NC patients with SRED were more frequently women (71% vs 39%, P = 0.013), had higher "bulimic" (29% vs 2%, P = 0.004) and "social insecurity" (48% vs 18%, P = 0.013) traits on the EDI-2, had higher obsessive-compulsiveness on the MOCI (29% vs 4%, P = 0.009), and were more depressed on the BDI (67% vs 29%, P = 0.005). NC patients with NS showed more frequent pathological profiles on the EDI-2 (100% vs 75%, P = 0.035), including the "bulimic" (29% vs 6%, P = 0.015), "perfectionism" (43% vs 14%, P = 0.016), and "social insecurity" (50% vs 22, P = 0.035) profiles. Conclusion: Our study shows a strong association of the compulsive nocturnal behaviors SRED and NS with adult NC.

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